Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice

Pituitary adenylate cyclase-activating polypeptide (PACAP) has neuroprotective and neurotrophic properties and is a potent alpha-secretase activator. As PACAP peptides and their specific receptor PAC1 are localized in central nervous system areas affected by Alzheimer's disease (AD), this study...

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Veröffentlicht in:	FASEB Journal 2011-09, Vol.25 (9), p.3208-3218
Hauptverfasser:	Rat, Dorothea, Schmitt, Ulrich, Tippmann, Frank, Dewachter, Ilse, Theunis, Clara, Wieczerzak, Ewa, Postina, Rolf, Van Leuven, Fred, Fahrenholz, Falk, Kojro, Elzbieta
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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