Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV type 1, HIV type 2, and selected carbohydrate-binding agent-resistant HIV type 1 strains

Abstract Carbohydrate-binding agents (CBAs) are potential HIV microbicidal agents with a high genetic barrier to resistance. We wanted to evaluate whether two mannose-specific CBAs, recognizing multiple and often distinct glycan structures on the HIV envelope gp120, can interact synergistically agai...

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Veröffentlicht in:	AIDS Research and Human Retroviruses 2012-11, Vol.28 (11), p.1513-1523
Hauptverfasser:	Férir, Geoffrey, Huskens, Dana, Palmer, Kenneth E, Boudreaux, Daniel M, Swanson, Michael D, Markovitz, David M, Balzarini, Jan, Schols, Dominique
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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