Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives

Microtubules are dynamic structures that play a crucial role in cellular division and are recognized as an important target for cancer therapy. In search of new compounds with strong antiproliferative activity and simple molecular structure, a new series of 2-amino-3-(3',4',5'-trimeth...

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Veröffentlicht in:	Bioorganic & Medicinal Chemistry Letters 2011-05, Vol.21 (9), p.2746-51
Hauptverfasser:	Romagnoli, Romeo, Baraldi, Pier Giovanni, Cruz-Lopez, Olga, Tolomeo, Manlio, Cristina, Antonietta Di, Pipitone, Rosaria Maria, Grimaudo, Stefania, Balzarini, Jan, Brancale, Andrea, Hamel, Ernest
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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