Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives

Microtubules are dynamic structures that play a crucial role in cellular division and are recognized as an important target for cancer therapy. In search of new compounds with strong antiproliferative activity and simple molecular structure, we have synthesized four different series of compounds in...

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Veröffentlicht in:	Medicinal Chemistry 2010-11, Vol.6 (6), p.329-343
Hauptverfasser:	Romagnoli, Romeo, Baraldi, Pier Giovanni, Pavani, Maria Giovanna, Cruz-Lopez, Olga, Hamel, Ernest, Balzarini, Jan, Brognara, Eleonora, Zuccato, Cristina, Gambari, Roberto
Format:	Artikel
Sprache:	eng
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