Gamma-secretase and the intramembrane proteolysis of Notch
Gamma-secretase is the crucial proteolytic activity that releases the Notch intracellular domain and is therefore a central player in the canonical Notch-signaling transduction pathway. We discuss here briefly the discovery of gamma-secretase and what is known on its structure and function. Recent w...
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| Veröffentlicht in: | Current Topics in Developmental Biology 2010, Vol.92 (C), p.201-30 |
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| container_title | Current Topics in Developmental Biology |
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| creator | Jorissen, Ellen De Strooper, Bart |
| description | Gamma-secretase is the crucial proteolytic activity that releases the Notch intracellular domain and is therefore a central player in the canonical Notch-signaling transduction pathway. We discuss here briefly the discovery of gamma-secretase and what is known on its structure and function. Recent work also indicates that the assembly and activity of gamma-secretase might be regulated by novel cell biological mechanisms. Finally we explore the recent insight that there are several gamma-secretase complexes in mammalian and discuss possibilities to use gamma-secretase as a drug target in Alzheimer's disease and cancer. |
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| title | Gamma-secretase and the intramembrane proteolysis of Notch |
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