Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers
Presently, the Caco-2 cell culture model is widely used during drug discovery and development as a predictive tool for the oral absorption of drug candidates. For transport experiments in the Caco-2 system, HBSS-like buffered salt solutions are commonly used, although different shortcomings have bee...
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| Veröffentlicht in: | International journal of pharmaceutics 2004-04, Vol.274 (1), p.221-32 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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