Simulated intestinal fluid as transport medium in the Caco-2 cell culture model

The Caco-2 model is widely used as a predictive tool for the oral absorption of drug candidates. Presently, transport experiments in the Caco-2 system are usually performed in 'HBSS-like' buffers. In this paper, we investigate the possibility of using simulated intestinal buffers as donor...

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Veröffentlicht in:	International journal of pharmaceutics 2002-01, Vol.232 (1), p.183-192
Hauptverfasser:	Ingels, F, Deferme, S, Destexhe, E, Oth, M, Van den Mooter, Guy, Augustijns, Patrick
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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