Straightforward C-8 alkylation of adenosine analogues with tetraalkyltin reagents
A one step synthesis of the 8-methyl-, 8-ethyl -and 8-vinyl derivatives of adenosine, 2′-deoxyadenosine and 2′,3′-dideoxyadenosine starting from the readily available 8-bromo congeners is described. This reaction makes use of a transient silylation procedure and a Pd(0) catalysed cross-coupling with...
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| Veröffentlicht in: | Tetrahedron letters 1992, Vol.33 (17), p.2413-2416 |
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| container_issue | 17 |
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| container_title | Tetrahedron letters |
| container_volume | 33 |
| creator | Mamos, P Van Aerschot, Arthur Weyns, N Herdewijn, Piet |
| description | A one step synthesis of the 8-methyl-, 8-ethyl -and 8-vinyl derivatives of adenosine, 2′-deoxyadenosine and 2′,3′-dideoxyadenosine starting from the readily available 8-bromo congeners is described. This reaction makes use of a transient silylation procedure and a Pd(0) catalysed cross-coupling with tetraorganotin reagents. © 1992. |
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This reaction makes use of a transient silylation procedure and a Pd(0) catalysed cross-coupling with tetraorganotin reagents. © 1992.</abstract><pub>Pergamon Press</pub></addata></record> |
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| ispartof | Tetrahedron letters, 1992, Vol.33 (17), p.2413-2416 |
| issn | 0040-4039 |
| language | eng |
| recordid | cdi_kuleuven_dspace_123456789_163415 |
| source | Lirias (KU Leuven Association); Elsevier ScienceDirect Journals Complete |
| title | Straightforward C-8 alkylation of adenosine analogues with tetraalkyltin reagents |
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