꽃며느리밥풀 Ethyl acetate 분획물의 예쁜 꼬마선충에 대한 항산화 효과

꽃며느리밥풀 Ethyl acetate 분획물의 예쁜 꼬마선충에 대한 항산화 효과

Caenorhabditis elegans model system was used to investigate the antioxidant activity of methanol extract of Melampyrum roseum (Scrophulariaceae). The ethyl acetate soluble fraction of the M. roseum methanol extract showed the best DPPH radical scavenging activity. The ethyl acetate fraction was meas...

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Veröffentlicht in:생약학회지 2022, Vol.53 (2), p.96-101
Hauptverfasser: 김준형(Jun Hyeong Kim), 박창범(Chang Bum Park), 박종현(Jong Hyun Park), 권강무(Kang Mu Kwon), 황인현(In Hyun Hwang), 마상용(Sang Yong Ma), 오석흥(Suk-Heung Oh), 김대근(Dae Keun Kim)
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container_issue 2
container_start_page 96
container_title 생약학회지
container_volume 53
creator 김준형(Jun Hyeong Kim)
박창범(Chang Bum Park)
박종현(Jong Hyun Park)
권강무(Kang Mu Kwon)
황인현(In Hyun Hwang)
마상용(Sang Yong Ma)
오석흥(Suk-Heung Oh)
김대근(Dae Keun Kim)
description Caenorhabditis elegans model system was used to investigate the antioxidant activity of methanol extract of Melampyrum roseum (Scrophulariaceae). The ethyl acetate soluble fraction of the M. roseum methanol extract showed the best DPPH radical scavenging activity. The ethyl acetate fraction was measured for the activity of superoxide dismutase (SOD), catalase, and oxidative stress tolerance by using C. elegans along with reactive oxygen species (ROS) level. In addition, to confirm that the regulation of the stress response gene is responsible for the increased stress tolerance of C. elegans treated by the ethyl acetate fraction, SOD-3 expression was measured using a transgenic strain. As a result, the ethyl acetate fraction increased SOD and catalase activity, and decreased ROS accumulation in a dose-dependent manner. In addition, the ethyl acetate fraction-treated CF1553 worm showed higher SOD-3::GFP intensity than the control worm.
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title 꽃며느리밥풀 Ethyl acetate 분획물의 예쁜 꼬마선충에 대한 항산화 효과
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