Novel GPR43 Agonists Exert an Anti-Inflammatory Effect in a Colitis Model

GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism. GPR43 couples with Gαi/o and Gαq/11 heterotrimeric proteins and is capable of decreasing cyclic AMP and inducing Ca 2+ flux....

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Veröffentlicht in:	Biomolecules & therapeutics 2022-01, Vol.30 (1), p.48-54
Hauptverfasser:	Park, Bi-Oh, Kang, Jong Soon, Paudel, Suresh, Park, Sung Goo, Park, Byoung Chul, Han, Sang-Bae, Kwak, Young-Shin, Kim, Jeong-Hoon, Kim, Sunhong
Format:	Artikel
Sprache:	kor
Schlagworte:	Allosteric agonists Anti-inflammation GPR43 NF-κB
Online-Zugang:	Volltext
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