Anti-melanogenesis Effects of Schizophragma hydrangeoides Leaf Ethanol Extracts via Downregulation of Tyrosinase Activity

Whitening agents derived from natural sources which do not have side effects are sought after. Schizophragma hydrangeoides is an edible plant that grows wild on Jeju Island. We aimed to determine whether S. hydrangeoides extracts show anti-melanogenic activity. Here, we found that 70% ethanol extrac...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:韓國資源植物學會誌 2021-12, Vol.34 (6), p.510-516
Hauptverfasser: 현호봉(Ho Bong Hyun), 현혜진(Hye Jin Hyeon), 김성천(Sung Chun Kim), 고보람(Boram Go), 윤선아(Seon-A Yoon), 정용환(Yong-Hwan Jung), 함영민(Young-Min Ham)
Format: Artikel
Sprache:kor
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 516
container_issue 6
container_start_page 510
container_title 韓國資源植物學會誌
container_volume 34
creator 현호봉(Ho Bong Hyun)
현혜진(Hye Jin Hyeon)
김성천(Sung Chun Kim)
고보람(Boram Go)
윤선아(Seon-A Yoon)
정용환(Yong-Hwan Jung)
함영민(Young-Min Ham)
description Whitening agents derived from natural sources which do not have side effects are sought after. Schizophragma hydrangeoides is an edible plant that grows wild on Jeju Island. We aimed to determine whether S. hydrangeoides extracts show anti-melanogenic activity. Here, we found that 70% ethanol extracts of S. hydrangeoides leaf suppressed α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 mouse melanoma cells. This activity of anti-melanogenesis in B16F10 cells were investigated by determining melanin content and tyrosinase activity, and by performing western blotting. The 70% ethanol extract downregulated tyrosinase and tyrosinase-related protein 1. In addition, the n-hexane fraction of S. hydrangeoides leaf (HFSH) exhibited significant anti-melanogenic activity among the various solvent fractions tested without reducing the viability of B16F10 cells. Taken together, these results indicate that extracts from S. hydrangeoides leaf can influence cellular processes via modulation of tyrosinase activity. Hence, S. hydrangeoides can be used as a whitening agent in the cosmetic industry and as a therapeutic agent for treating hyperpigmentation disorders in the clinic.
format Article
fullrecord <record><control><sourceid>kyobo_kisti</sourceid><recordid>TN_cdi_kisti_ndsl_JAKO202108149230776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4010028669547</sourcerecordid><originalsourceid>FETCH-LOGICAL-k607-4b67f14c498e5a5690e040b58860b023c1242e1aa9f12b1f5df1c129781687bd3</originalsourceid><addsrcrecordid>eNpNj11LwzAYhYsoOHT_ITdeFt6kaZJeljk_B7tw9yVp37RhXSJNnNZf74ZeeHXgcJ4HzkW2YEzJXDEoLrMFZUzkRVnR62wZozMAQipaCr7I5tonlx9w1D706DG6SNbWYpsiCZa8tYP7Du_DpPuDJsPcTdr3GFyHkWxQW7JOw4kcyforTfoMHZ0m9-HTT9h_jDq54M-e3TyF6LyOSOo2uaNL8212ZfUYcfmXN9nuYb1bPeWb7ePzqt7kewEy50ZIS3nLK4WlLkUFCBxMqZQAA6xoKeMMqdaVpcxQW3aWnrrq9E8oabriJrv71e5dTK7xXRybl_p1y4BRUJRXrAApxb_dHExoTAj7Fn3CqeFAAZgSoiq5LH4AqkFmjQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Anti-melanogenesis Effects of Schizophragma hydrangeoides Leaf Ethanol Extracts via Downregulation of Tyrosinase Activity</title><source>KoreaScience</source><source>Free E-Journal (出版社公開部分のみ)</source><creator>현호봉(Ho Bong Hyun) ; 현혜진(Hye Jin Hyeon) ; 김성천(Sung Chun Kim) ; 고보람(Boram Go) ; 윤선아(Seon-A Yoon) ; 정용환(Yong-Hwan Jung) ; 함영민(Young-Min Ham)</creator><creatorcontrib>현호봉(Ho Bong Hyun) ; 현혜진(Hye Jin Hyeon) ; 김성천(Sung Chun Kim) ; 고보람(Boram Go) ; 윤선아(Seon-A Yoon) ; 정용환(Yong-Hwan Jung) ; 함영민(Young-Min Ham)</creatorcontrib><description>Whitening agents derived from natural sources which do not have side effects are sought after. Schizophragma hydrangeoides is an edible plant that grows wild on Jeju Island. We aimed to determine whether S. hydrangeoides extracts show anti-melanogenic activity. Here, we found that 70% ethanol extracts of S. hydrangeoides leaf suppressed α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 mouse melanoma cells. This activity of anti-melanogenesis in B16F10 cells were investigated by determining melanin content and tyrosinase activity, and by performing western blotting. The 70% ethanol extract downregulated tyrosinase and tyrosinase-related protein 1. In addition, the n-hexane fraction of S. hydrangeoides leaf (HFSH) exhibited significant anti-melanogenic activity among the various solvent fractions tested without reducing the viability of B16F10 cells. Taken together, these results indicate that extracts from S. hydrangeoides leaf can influence cellular processes via modulation of tyrosinase activity. Hence, S. hydrangeoides can be used as a whitening agent in the cosmetic industry and as a therapeutic agent for treating hyperpigmentation disorders in the clinic.</description><identifier>ISSN: 1226-3591</identifier><identifier>EISSN: 2287-8203</identifier><language>kor</language><publisher>The Plant Resources Society Of Korea</publisher><ispartof>韓國資源植物學會誌, 2021-12, Vol.34 (6), p.510-516</ispartof><rights>COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27011</link.rule.ids></links><search><creatorcontrib>현호봉(Ho Bong Hyun)</creatorcontrib><creatorcontrib>현혜진(Hye Jin Hyeon)</creatorcontrib><creatorcontrib>김성천(Sung Chun Kim)</creatorcontrib><creatorcontrib>고보람(Boram Go)</creatorcontrib><creatorcontrib>윤선아(Seon-A Yoon)</creatorcontrib><creatorcontrib>정용환(Yong-Hwan Jung)</creatorcontrib><creatorcontrib>함영민(Young-Min Ham)</creatorcontrib><title>Anti-melanogenesis Effects of Schizophragma hydrangeoides Leaf Ethanol Extracts via Downregulation of Tyrosinase Activity</title><title>韓國資源植物學會誌</title><addtitle>Korean journal of plant resources</addtitle><description>Whitening agents derived from natural sources which do not have side effects are sought after. Schizophragma hydrangeoides is an edible plant that grows wild on Jeju Island. We aimed to determine whether S. hydrangeoides extracts show anti-melanogenic activity. Here, we found that 70% ethanol extracts of S. hydrangeoides leaf suppressed α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 mouse melanoma cells. This activity of anti-melanogenesis in B16F10 cells were investigated by determining melanin content and tyrosinase activity, and by performing western blotting. The 70% ethanol extract downregulated tyrosinase and tyrosinase-related protein 1. In addition, the n-hexane fraction of S. hydrangeoides leaf (HFSH) exhibited significant anti-melanogenic activity among the various solvent fractions tested without reducing the viability of B16F10 cells. Taken together, these results indicate that extracts from S. hydrangeoides leaf can influence cellular processes via modulation of tyrosinase activity. Hence, S. hydrangeoides can be used as a whitening agent in the cosmetic industry and as a therapeutic agent for treating hyperpigmentation disorders in the clinic.</description><issn>1226-3591</issn><issn>2287-8203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>JDI</sourceid><recordid>eNpNj11LwzAYhYsoOHT_ITdeFt6kaZJeljk_B7tw9yVp37RhXSJNnNZf74ZeeHXgcJ4HzkW2YEzJXDEoLrMFZUzkRVnR62wZozMAQipaCr7I5tonlx9w1D706DG6SNbWYpsiCZa8tYP7Du_DpPuDJsPcTdr3GFyHkWxQW7JOw4kcyforTfoMHZ0m9-HTT9h_jDq54M-e3TyF6LyOSOo2uaNL8212ZfUYcfmXN9nuYb1bPeWb7ePzqt7kewEy50ZIS3nLK4WlLkUFCBxMqZQAA6xoKeMMqdaVpcxQW3aWnrrq9E8oabriJrv71e5dTK7xXRybl_p1y4BRUJRXrAApxb_dHExoTAj7Fn3CqeFAAZgSoiq5LH4AqkFmjQ</recordid><startdate>20211231</startdate><enddate>20211231</enddate><creator>현호봉(Ho Bong Hyun)</creator><creator>현혜진(Hye Jin Hyeon)</creator><creator>김성천(Sung Chun Kim)</creator><creator>고보람(Boram Go)</creator><creator>윤선아(Seon-A Yoon)</creator><creator>정용환(Yong-Hwan Jung)</creator><creator>함영민(Young-Min Ham)</creator><general>The Plant Resources Society Of Korea</general><general>한국자원식물학회</general><scope>P5Y</scope><scope>SSSTE</scope><scope>JDI</scope></search><sort><creationdate>20211231</creationdate><title>Anti-melanogenesis Effects of Schizophragma hydrangeoides Leaf Ethanol Extracts via Downregulation of Tyrosinase Activity</title><author>현호봉(Ho Bong Hyun) ; 현혜진(Hye Jin Hyeon) ; 김성천(Sung Chun Kim) ; 고보람(Boram Go) ; 윤선아(Seon-A Yoon) ; 정용환(Yong-Hwan Jung) ; 함영민(Young-Min Ham)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k607-4b67f14c498e5a5690e040b58860b023c1242e1aa9f12b1f5df1c129781687bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2021</creationdate><toplevel>online_resources</toplevel><creatorcontrib>현호봉(Ho Bong Hyun)</creatorcontrib><creatorcontrib>현혜진(Hye Jin Hyeon)</creatorcontrib><creatorcontrib>김성천(Sung Chun Kim)</creatorcontrib><creatorcontrib>고보람(Boram Go)</creatorcontrib><creatorcontrib>윤선아(Seon-A Yoon)</creatorcontrib><creatorcontrib>정용환(Yong-Hwan Jung)</creatorcontrib><creatorcontrib>함영민(Young-Min Ham)</creatorcontrib><collection>교보문고 스콜라</collection><collection>Scholar(스콜라)</collection><collection>KoreaScience</collection><jtitle>韓國資源植物學會誌</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>현호봉(Ho Bong Hyun)</au><au>현혜진(Hye Jin Hyeon)</au><au>김성천(Sung Chun Kim)</au><au>고보람(Boram Go)</au><au>윤선아(Seon-A Yoon)</au><au>정용환(Yong-Hwan Jung)</au><au>함영민(Young-Min Ham)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-melanogenesis Effects of Schizophragma hydrangeoides Leaf Ethanol Extracts via Downregulation of Tyrosinase Activity</atitle><jtitle>韓國資源植物學會誌</jtitle><addtitle>Korean journal of plant resources</addtitle><date>2021-12-31</date><risdate>2021</risdate><volume>34</volume><issue>6</issue><spage>510</spage><epage>516</epage><pages>510-516</pages><issn>1226-3591</issn><eissn>2287-8203</eissn><abstract>Whitening agents derived from natural sources which do not have side effects are sought after. Schizophragma hydrangeoides is an edible plant that grows wild on Jeju Island. We aimed to determine whether S. hydrangeoides extracts show anti-melanogenic activity. Here, we found that 70% ethanol extracts of S. hydrangeoides leaf suppressed α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 mouse melanoma cells. This activity of anti-melanogenesis in B16F10 cells were investigated by determining melanin content and tyrosinase activity, and by performing western blotting. The 70% ethanol extract downregulated tyrosinase and tyrosinase-related protein 1. In addition, the n-hexane fraction of S. hydrangeoides leaf (HFSH) exhibited significant anti-melanogenic activity among the various solvent fractions tested without reducing the viability of B16F10 cells. Taken together, these results indicate that extracts from S. hydrangeoides leaf can influence cellular processes via modulation of tyrosinase activity. Hence, S. hydrangeoides can be used as a whitening agent in the cosmetic industry and as a therapeutic agent for treating hyperpigmentation disorders in the clinic.</abstract><pub>The Plant Resources Society Of Korea</pub><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1226-3591
ispartof 韓國資源植物學會誌, 2021-12, Vol.34 (6), p.510-516
issn 1226-3591
2287-8203
language kor
recordid cdi_kisti_ndsl_JAKO202108149230776
source KoreaScience; Free E-Journal (出版社公開部分のみ)
title Anti-melanogenesis Effects of Schizophragma hydrangeoides Leaf Ethanol Extracts via Downregulation of Tyrosinase Activity
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A53%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-kyobo_kisti&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-melanogenesis%20Effects%20of%20Schizophragma%20hydrangeoides%20Leaf%20Ethanol%20Extracts%20via%20Downregulation%20of%20Tyrosinase%20Activity&rft.jtitle=%E9%9F%93%E5%9C%8B%E8%B3%87%E6%BA%90%E6%A4%8D%E7%89%A9%E5%AD%B8%E6%9C%83%E8%AA%8C&rft.au=%ED%98%84%ED%98%B8%EB%B4%89(Ho%20Bong%20Hyun)&rft.date=2021-12-31&rft.volume=34&rft.issue=6&rft.spage=510&rft.epage=516&rft.pages=510-516&rft.issn=1226-3591&rft.eissn=2287-8203&rft_id=info:doi/&rft_dat=%3Ckyobo_kisti%3E4010028669547%3C/kyobo_kisti%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true