Engineering of Biosynthesis Pathway and NADPH Supply for Improved L-5-Methyltetrahydrofolate Production by Lactococcus lactis

L-5-methyltetrahydrofolate (5-MTHF) is one of the biological active forms of folate, which is widely used as a nutraceutical. However, low yield and serious pollution associated with the chemical synthesis of 5-MTHF hampers its sustainable supply. In this study, 5-MTHF production was improved by eng...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2021-01, Vol.31 (1), p.154-162
Hauptverfasser:	Lu, Chuanchuan, Liu, Yanfeng, Li, Jianghua, Liu, Long, Du, Guocheng
Format:	Artikel
Sprache:	kor
Schlagworte:	L-5-Methyltetrahydrofolate Lactococcus lactis metabolic engineering NADPH supply strengthening synthetic pathway
Online-Zugang:	Volltext
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