Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain
Background: This study aimed to assess the potential efficacy of purified porcine atelocollagen (PAC) for the management of refractory chronic pain due to suspected connective tissue damage. Methods: Patients treated with PAC were retrospectively evaluated. Patients with chronic refractory pain, sus...
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| Veröffentlicht in: | The Korean journal of pain 2020-10, Vol.33 (4), p.395-399 |
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| container_title | The Korean journal of pain |
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| creator | Seong, Hyunyoung Kim, Raing Kyu Shin, Youngjae Lee, Hye Won Koh, Jae Chul |
| description | Background: This study aimed to assess the potential efficacy of purified porcine atelocollagen (PAC) for the management of refractory chronic pain due to suspected connective tissue damage.
Methods: Patients treated with PAC were retrospectively evaluated. Patients with chronic refractory pain, suspected to have originated from musculoskeletal damage or defects with the evidence of imaging studies were included. Pain intensity, using the 11-point numerical rating scale (NRS), was assessed before the procedure, and 1 month after the last procedure.
Results: Eighty-eight patients were finally included for investigation. The mean NRS score was decreased from 5.8 to 4.1 after 1 month of PAC injection (P < 0.001). No independent factor was reported to be directly related to the decrease in NRS score by more than half.
Conclusions: Application of PAC may have potential as a treatment option for refractory chronic musculoskeletal pain. PAC might promote tissue recovery, act as a scaffold for repair, or directly reduce inflammation. |
| format | Article |
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Methods: Patients treated with PAC were retrospectively evaluated. Patients with chronic refractory pain, suspected to have originated from musculoskeletal damage or defects with the evidence of imaging studies were included. Pain intensity, using the 11-point numerical rating scale (NRS), was assessed before the procedure, and 1 month after the last procedure.
Results: Eighty-eight patients were finally included for investigation. The mean NRS score was decreased from 5.8 to 4.1 after 1 month of PAC injection (P < 0.001). No independent factor was reported to be directly related to the decrease in NRS score by more than half.
Conclusions: Application of PAC may have potential as a treatment option for refractory chronic musculoskeletal pain. PAC might promote tissue recovery, act as a scaffold for repair, or directly reduce inflammation.</description><identifier>ISSN: 2005-9159</identifier><identifier>EISSN: 2093-0569</identifier><language>kor</language><publisher>대한통증학회</publisher><subject>Chronic Pain ; Collagen ; Connective Tissue ; Injections ; Musculoskeletal Pain ; Pain Management ; Procollagen ; Regenerative Medicine</subject><ispartof>The Korean journal of pain, 2020-10, Vol.33 (4), p.395-399</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881</link.rule.ids></links><search><creatorcontrib>Seong, Hyunyoung</creatorcontrib><creatorcontrib>Kim, Raing Kyu</creatorcontrib><creatorcontrib>Shin, Youngjae</creatorcontrib><creatorcontrib>Lee, Hye Won</creatorcontrib><creatorcontrib>Koh, Jae Chul</creatorcontrib><title>Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain</title><title>The Korean journal of pain</title><addtitle>The Korean Journal of Pain</addtitle><description>Background: This study aimed to assess the potential efficacy of purified porcine atelocollagen (PAC) for the management of refractory chronic pain due to suspected connective tissue damage.
Methods: Patients treated with PAC were retrospectively evaluated. Patients with chronic refractory pain, suspected to have originated from musculoskeletal damage or defects with the evidence of imaging studies were included. Pain intensity, using the 11-point numerical rating scale (NRS), was assessed before the procedure, and 1 month after the last procedure.
Results: Eighty-eight patients were finally included for investigation. The mean NRS score was decreased from 5.8 to 4.1 after 1 month of PAC injection (P < 0.001). No independent factor was reported to be directly related to the decrease in NRS score by more than half.
Conclusions: Application of PAC may have potential as a treatment option for refractory chronic musculoskeletal pain. PAC might promote tissue recovery, act as a scaffold for repair, or directly reduce inflammation.</description><subject>Chronic Pain</subject><subject>Collagen</subject><subject>Connective Tissue</subject><subject>Injections</subject><subject>Musculoskeletal Pain</subject><subject>Pain Management</subject><subject>Procollagen</subject><subject>Regenerative Medicine</subject><issn>2005-9159</issn><issn>2093-0569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>JDI</sourceid><recordid>eNo9jj9rwzAUxE1poSHNJ-iipaNBkSxbGkPo3wSyZDfy81PzsCIZyaHk29elpdxwN_zuuJtiIbiRJVe1uf3JXJVmrcx9scqZOq54I6vGyEVhN-PoCexEMbDo2HhJ5Ah7NsYEFJBB9N5-YmAU2DhjGKbMvmg6MTilGAhYQpcsTDFd2fmS4eJjHtDjZP1coPBQ3DnrM67-fFkcX56P27dyf3h932725aDmd6JxQjreGVCyc9LavgeUvKtQW4TKoUatwGgw6951TklVGYFCYIN1XSHIZfH0OztQnqgNffbtx2Z3EHyW1moteM0bNXOP_1xux0Rnm66t1MJwVclvOBRdRg</recordid><startdate>20201031</startdate><enddate>20201031</enddate><creator>Seong, Hyunyoung</creator><creator>Kim, Raing Kyu</creator><creator>Shin, Youngjae</creator><creator>Lee, Hye Won</creator><creator>Koh, Jae Chul</creator><general>대한통증학회</general><scope>HZB</scope><scope>Q5X</scope><scope>JDI</scope></search><sort><creationdate>20201031</creationdate><title>Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain</title><author>Seong, Hyunyoung ; Kim, Raing Kyu ; Shin, Youngjae ; Lee, Hye Won ; Koh, Jae Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k505-27f23f0b9c53bf3aaddce30b4e8aec4fe8e85c98c91dfbf535492e22e7e664ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2020</creationdate><topic>Chronic Pain</topic><topic>Collagen</topic><topic>Connective Tissue</topic><topic>Injections</topic><topic>Musculoskeletal Pain</topic><topic>Pain Management</topic><topic>Procollagen</topic><topic>Regenerative Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seong, Hyunyoung</creatorcontrib><creatorcontrib>Kim, Raing Kyu</creatorcontrib><creatorcontrib>Shin, Youngjae</creatorcontrib><creatorcontrib>Lee, Hye Won</creatorcontrib><creatorcontrib>Koh, Jae Chul</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><collection>KoreaScience</collection><jtitle>The Korean journal of pain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seong, Hyunyoung</au><au>Kim, Raing Kyu</au><au>Shin, Youngjae</au><au>Lee, Hye Won</au><au>Koh, Jae Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain</atitle><jtitle>The Korean journal of pain</jtitle><addtitle>The Korean Journal of Pain</addtitle><date>2020-10-31</date><risdate>2020</risdate><volume>33</volume><issue>4</issue><spage>395</spage><epage>399</epage><pages>395-399</pages><issn>2005-9159</issn><eissn>2093-0569</eissn><abstract>Background: This study aimed to assess the potential efficacy of purified porcine atelocollagen (PAC) for the management of refractory chronic pain due to suspected connective tissue damage.
Methods: Patients treated with PAC were retrospectively evaluated. Patients with chronic refractory pain, suspected to have originated from musculoskeletal damage or defects with the evidence of imaging studies were included. Pain intensity, using the 11-point numerical rating scale (NRS), was assessed before the procedure, and 1 month after the last procedure.
Results: Eighty-eight patients were finally included for investigation. The mean NRS score was decreased from 5.8 to 4.1 after 1 month of PAC injection (P < 0.001). No independent factor was reported to be directly related to the decrease in NRS score by more than half.
Conclusions: Application of PAC may have potential as a treatment option for refractory chronic musculoskeletal pain. PAC might promote tissue recovery, act as a scaffold for repair, or directly reduce inflammation.</abstract><pub>대한통증학회</pub><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2005-9159 |
| ispartof | The Korean journal of pain, 2020-10, Vol.33 (4), p.395-399 |
| issn | 2005-9159 2093-0569 |
| language | kor |
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| source | KoreaMed Synapse; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Chronic Pain Collagen Connective Tissue Injections Musculoskeletal Pain Pain Management Procollagen Regenerative Medicine |
| title | Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain |
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