Investigation of function and regulation of the YB-1 cellular factor in HIV replication
Y-box binding protein 1 (YB-1) is a member of the cold-shock domain (CSD) protein superfamily. It participates in a wide variety of cellular events, including transcription, RNA splicing, translation, DNA repair, drug resistance, and stress responses. We investigated putative functions of YB-1 in HI...
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| Veröffentlicht in: | BMB reports 2018-06, Vol.51 (6), p.290-295 |
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| creator | Jung, Yu-Mi Yu, Kyung-Lee Park, Seong-Hyun Lee, Seong-Deok Kim, Min-Jeong You, Ji-Chang |
| description | Y-box binding protein 1 (YB-1) is a member of the cold-shock domain (CSD) protein superfamily. It participates in a wide variety of cellular events, including transcription, RNA splicing, translation, DNA repair, drug resistance, and stress responses. We investigated putative functions of YB-1 in HIV-1 replication. Functional studies using overexpression or knockdown of YB-1 in conjunction with transfection of proviral DNA showed that YB-1 enhances virus production. We found YB-1 regulates HIV-1 production by stimulating viral transcription using HIV-1 LTR sequence U3RU5 with Luciferase assay. We also identified a specific region from amino acids 1 to 324 of YB-1 as necessary for the participation of the protein in the production of virions. [BMB Reports 2018; 51(6): 290-295] |
| format | Article |
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It participates in a wide variety of cellular events, including transcription, RNA splicing, translation, DNA repair, drug resistance, and stress responses. We investigated putative functions of YB-1 in HIV-1 replication. Functional studies using overexpression or knockdown of YB-1 in conjunction with transfection of proviral DNA showed that YB-1 enhances virus production. We found YB-1 regulates HIV-1 production by stimulating viral transcription using HIV-1 LTR sequence U3RU5 with Luciferase assay. We also identified a specific region from amino acids 1 to 324 of YB-1 as necessary for the participation of the protein in the production of virions. 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| fulltext | fulltext |
| identifier | ISSN: 1976-6696 |
| ispartof | BMB reports, 2018-06, Vol.51 (6), p.290-295 |
| issn | 1976-6696 1976-670X |
| language | kor |
| recordid | cdi_kisti_ndsl_JAKO201819352298875 |
| source | PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | HIV-1 HIV-1 LTR HIV-1 promoter Transcription activation YB-1 |
| title | Investigation of function and regulation of the YB-1 cellular factor in HIV replication |
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