Repression of the F-box protein Skp2 is essential for actin damage-induced tetraploid G1 arrest

We previously reported that p53 plays a role as a key regulator in the tetraploid G1 checkpoint, which is activated by actin damage-induced cytokinesis blockade and then prevents uncoupled DNA replication and nuclear division without cytokinesis. In this study, we investigated a role of Skp2, which...

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Veröffentlicht in:	BMB reports 2017-07, Vol.50 (7), p.379-383
Hauptverfasser:	Jo, Yongsam, Shin, Deug Y
Format:	Artikel
Sprache:	kor
Schlagworte:	Actin damage Cytokinesis Pectenotoxin-2 Skp2 Tetra-ploid G1 arrest
Online-Zugang:	Volltext
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