Structure-Based Virtual Screening of Protein Tyrosine Phosphatase Inhibitors: Significance, Challenges, and Solutions

Phosphorylation, a critical mechanism in biological systems, is estimated to be indispensable for about 30% of key biological activities, such as cell cycle progression, migration, and division. It is synergistically balanced by kinases and phosphatases, and any deviation from this balance leads to...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2017-05, Vol.27 (5), p.878-895
Hauptverfasser:	Reddy, Rallabandi Harikrishna, Kim, Hackyoung, Cha, Seungbin, Lee, Bongsoo, Kim, Young Jun
Format:	Artikel
Sprache:	kor
Schlagworte:	Allosteric targeting cancers diabetes drug designing molecular docking protein tyrosine phosphatases
Online-Zugang:	Volltext
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