Prognostic Role of PTEN Gene Expression in Breast Cancer Patients from North-East Iran

Prognostic Role of PTEN Gene Expression in Breast Cancer Patients from North-East Iran

Background: PTEN protein is one of the most important tumour suppressor factors which is detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical stud...

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Veröffentlicht in:Asian Pacific journal of cancer prevention : APJCP 2016, Vol.17 (9), p.4527-4531
Hauptverfasser: Golmohammadi, Rahim, Rakhshani, Mohammad Hassan, Moslem, Ali Reza, Pejhan, Akbar
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container_issue 9
container_start_page 4527
container_title Asian Pacific journal of cancer prevention : APJCP
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creator Golmohammadi, Rahim
Rakhshani, Mohammad Hassan
Moslem, Ali Reza
Pejhan, Akbar
description Background: PTEN protein is one of the most important tumour suppressor factors which is detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical study was conducted on 100 breast cancer patients referred to Sabzevar hospitals in the north-east of Iran between 2010 and 2011, who were followed up to 2015. PTEN gene expression in tissue samples was determined using specific monoclonal antibodies and data were analyzed using Chi-square test and Fisher's exact test. Patient survival was analyzed after 4 years of follow-up using the Cox regression model. Results: PTEN gene expression was evident in 70 of 100 cnacer samples but was found at high levels in all non-cancer samples. There was an inverse significant relationship between PTEN gene expression and tumour stage or tumour grade (p
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The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical study was conducted on 100 breast cancer patients referred to Sabzevar hospitals in the north-east of Iran between 2010 and 2011, who were followed up to 2015. PTEN gene expression in tissue samples was determined using specific monoclonal antibodies and data were analyzed using Chi-square test and Fisher's exact test. Patient survival was analyzed after 4 years of follow-up using the Cox regression model. Results: PTEN gene expression was evident in 70 of 100 cnacer samples but was found at high levels in all non-cancer samples. There was an inverse significant relationship between PTEN gene expression and tumour stage or tumour grade (p&lt;0.001). The expression of PTEN in invasive ductal tumours was lower than in non-invasive tumours. There was also an inverse significant relationship between the hazard of death and PTEN gene expression (p&lt;0.001). In addition, there was an inverse significant relationship between tumour stage and hazard of death (p&lt;0.001). Conclusion: These findings indicate that lack of PTEN gene expression can be a sign of a worse prognosis and poor survival in breast cancer cases.</description><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><language>kor</language><ispartof>Asian Pacific journal of cancer prevention : APJCP, 2016, Vol.17 (9), p.4527-4531</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,4026</link.rule.ids></links><search><creatorcontrib>Golmohammadi, Rahim</creatorcontrib><creatorcontrib>Rakhshani, Mohammad Hassan</creatorcontrib><creatorcontrib>Moslem, Ali Reza</creatorcontrib><creatorcontrib>Pejhan, Akbar</creatorcontrib><title>Prognostic Role of PTEN Gene Expression in Breast Cancer Patients from North-East Iran</title><title>Asian Pacific journal of cancer prevention : APJCP</title><addtitle>Asian Pacific journal of cancer prevention : APJCP</addtitle><description>Background: PTEN protein is one of the most important tumour suppressor factors which is detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical study was conducted on 100 breast cancer patients referred to Sabzevar hospitals in the north-east of Iran between 2010 and 2011, who were followed up to 2015. PTEN gene expression in tissue samples was determined using specific monoclonal antibodies and data were analyzed using Chi-square test and Fisher's exact test. Patient survival was analyzed after 4 years of follow-up using the Cox regression model. Results: PTEN gene expression was evident in 70 of 100 cnacer samples but was found at high levels in all non-cancer samples. There was an inverse significant relationship between PTEN gene expression and tumour stage or tumour grade (p&lt;0.001). The expression of PTEN in invasive ductal tumours was lower than in non-invasive tumours. There was also an inverse significant relationship between the hazard of death and PTEN gene expression (p&lt;0.001). In addition, there was an inverse significant relationship between tumour stage and hazard of death (p&lt;0.001). 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The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical study was conducted on 100 breast cancer patients referred to Sabzevar hospitals in the north-east of Iran between 2010 and 2011, who were followed up to 2015. PTEN gene expression in tissue samples was determined using specific monoclonal antibodies and data were analyzed using Chi-square test and Fisher's exact test. Patient survival was analyzed after 4 years of follow-up using the Cox regression model. Results: PTEN gene expression was evident in 70 of 100 cnacer samples but was found at high levels in all non-cancer samples. There was an inverse significant relationship between PTEN gene expression and tumour stage or tumour grade (p&lt;0.001). The expression of PTEN in invasive ductal tumours was lower than in non-invasive tumours. There was also an inverse significant relationship between the hazard of death and PTEN gene expression (p&lt;0.001). In addition, there was an inverse significant relationship between tumour stage and hazard of death (p&lt;0.001). Conclusion: These findings indicate that lack of PTEN gene expression can be a sign of a worse prognosis and poor survival in breast cancer cases.</abstract><oa>free_for_read</oa></addata></record>
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title Prognostic Role of PTEN Gene Expression in Breast Cancer Patients from North-East Iran
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