Association of a p53 Codon 72 Gene Polymorphism with Environmental Factors and Risk of Lung Cancer: a Case Control Study in Mizoram and Manipur, a High Incidence Region in North East India
Background: A very high incidence of lung cancer is observed in Mizoram and Manipur, North East India. We conducted a population based case control study to establish associations of p53 codon 72 polymorphisms and interactions with environmental factors for this high incidence. Material and Methods:...
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| Veröffentlicht in: | Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 (24), p.10653-10658 |
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| container_title | Asian Pacific journal of cancer prevention : APJCP |
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| creator | Saikia, Bhaskar Jyoti Das, Mandakini Sharma, Santanu Kumar Sekhon, Gaganpreet Singh Zomawia, Eric Singh, Yanglem Mohen Mahanta, Jagadish Phukan, Rup Kumar |
| description | Background: A very high incidence of lung cancer is observed in Mizoram and Manipur, North East India. We conducted a population based case control study to establish associations of p53 codon 72 polymorphisms and interactions with environmental factors for this high incidence. Material and Methods: A total of 272 lung cancer cases and 544 controls matched for age (${\pm}5years$), sex and ethnicity were collected and p53 codon 72 polymorphism genotypes were analyzed using a polymerase chain based restriction fragment length polymorphism assay. We used conditional multiple logistic regression analysis to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: p53 Pro/Pro genotype was significantly associated with increased risk of lung cancer in the study population (adjusted OR=2.14, CI=1.35-3.38, p=0.001). Interactions of the p53 Pro/Pro genotype with exposure to wood smoke (adjusted OR=3.60, CI=1.85-6.98, p |
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We conducted a population based case control study to establish associations of p53 codon 72 polymorphisms and interactions with environmental factors for this high incidence. Material and Methods: A total of 272 lung cancer cases and 544 controls matched for age (${\pm}5years$), sex and ethnicity were collected and p53 codon 72 polymorphism genotypes were analyzed using a polymerase chain based restriction fragment length polymorphism assay. We used conditional multiple logistic regression analysis to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: p53 Pro/Pro genotype was significantly associated with increased risk of lung cancer in the study population (adjusted OR=2.14, CI=1.35-3.38, p=0.001). Interactions of the p53 Pro/Pro genotype with exposure to wood smoke (adjusted OR=3.60, CI=1.85-6.98, p<0.001) and cooking oil fumes (adjusted OR=3.27, CI=1.55-6.87, p=0.002), betel quid chewing (adjusted OR=3.85, CI=1.96-7.55, p<0.001), tobacco smoking (adjusted OR=4.42, CI=2.27-8.63, p<0.001) and alcohol consumption (adjusted OR=3.31, CI=1.10-10.03, p=0.034) were significant regarding the increased risk of lung cancer in the study population. Conclusions: The present study provided preliminary evidence that a p53 codon 72 polymorphism may effect lung cancer risk in the study population, interacting synergistically with environmental factors.</description><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><language>kor</language><ispartof>Asian Pacific journal of cancer prevention : APJCP, 2014, Vol.15 (24), p.10653-10658</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024</link.rule.ids></links><search><creatorcontrib>Saikia, Bhaskar Jyoti</creatorcontrib><creatorcontrib>Das, Mandakini</creatorcontrib><creatorcontrib>Sharma, Santanu Kumar</creatorcontrib><creatorcontrib>Sekhon, Gaganpreet Singh</creatorcontrib><creatorcontrib>Zomawia, Eric</creatorcontrib><creatorcontrib>Singh, Yanglem Mohen</creatorcontrib><creatorcontrib>Mahanta, Jagadish</creatorcontrib><creatorcontrib>Phukan, Rup Kumar</creatorcontrib><title>Association of a p53 Codon 72 Gene Polymorphism with Environmental Factors and Risk of Lung Cancer: a Case Control Study in Mizoram and Manipur, a High Incidence Region in North East India</title><title>Asian Pacific journal of cancer prevention : APJCP</title><addtitle>Asian Pacific journal of cancer prevention : APJCP</addtitle><description>Background: A very high incidence of lung cancer is observed in Mizoram and Manipur, North East India. We conducted a population based case control study to establish associations of p53 codon 72 polymorphisms and interactions with environmental factors for this high incidence. Material and Methods: A total of 272 lung cancer cases and 544 controls matched for age (${\pm}5years$), sex and ethnicity were collected and p53 codon 72 polymorphism genotypes were analyzed using a polymerase chain based restriction fragment length polymorphism assay. We used conditional multiple logistic regression analysis to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: p53 Pro/Pro genotype was significantly associated with increased risk of lung cancer in the study population (adjusted OR=2.14, CI=1.35-3.38, p=0.001). Interactions of the p53 Pro/Pro genotype with exposure to wood smoke (adjusted OR=3.60, CI=1.85-6.98, p<0.001) and cooking oil fumes (adjusted OR=3.27, CI=1.55-6.87, p=0.002), betel quid chewing (adjusted OR=3.85, CI=1.96-7.55, p<0.001), tobacco smoking (adjusted OR=4.42, CI=2.27-8.63, p<0.001) and alcohol consumption (adjusted OR=3.31, CI=1.10-10.03, p=0.034) were significant regarding the increased risk of lung cancer in the study population. Conclusions: The present study provided preliminary evidence that a p53 codon 72 polymorphism may effect lung cancer risk in the study population, interacting synergistically with environmental factors.</description><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>JDI</sourceid><recordid>eNqNjkFOwzAQRSMEEhH0DrNhR6TEdhJgV0UtpVBAhQW7ysRuMmoyjmwXVM7G4XAQB2A1Gs37b_5RFDNRFklZsLfjKM7yjCclL65Oo4lz-J4KUfK0ECKOvqfOmRqlR0NgtiBhyDlURoW1ZHCrScOz6Q69sUOLrodP9C3M6AOtoV6Tlx3MZe2NdSBJwRrdbvQ87KmBSlKt7U2QVtLpYCVvTQcvfq8OgAQr_DJW9r_BlSQc9vYywAtsWrijGpUOeVjrZiwX-Edjx-fS-XBWKM-jk63snJ78zbPoYj57rRbJDp3HDSnXbZbT-yeWZnlaMC7Ytcjygv-X-wG752PE</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Saikia, Bhaskar Jyoti</creator><creator>Das, Mandakini</creator><creator>Sharma, Santanu Kumar</creator><creator>Sekhon, Gaganpreet Singh</creator><creator>Zomawia, Eric</creator><creator>Singh, Yanglem Mohen</creator><creator>Mahanta, Jagadish</creator><creator>Phukan, Rup Kumar</creator><scope>JDI</scope></search><sort><creationdate>2014</creationdate><title>Association of a p53 Codon 72 Gene Polymorphism with Environmental Factors and Risk of Lung Cancer: a Case Control Study in Mizoram and Manipur, a High Incidence Region in North East India</title><author>Saikia, Bhaskar Jyoti ; Das, Mandakini ; Sharma, Santanu Kumar ; Sekhon, Gaganpreet Singh ; Zomawia, Eric ; Singh, Yanglem Mohen ; Mahanta, Jagadish ; Phukan, Rup Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kisti_ndsl_JAKO2015062342941563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saikia, Bhaskar Jyoti</creatorcontrib><creatorcontrib>Das, Mandakini</creatorcontrib><creatorcontrib>Sharma, Santanu Kumar</creatorcontrib><creatorcontrib>Sekhon, Gaganpreet Singh</creatorcontrib><creatorcontrib>Zomawia, Eric</creatorcontrib><creatorcontrib>Singh, Yanglem Mohen</creatorcontrib><creatorcontrib>Mahanta, Jagadish</creatorcontrib><creatorcontrib>Phukan, Rup Kumar</creatorcontrib><collection>KoreaScience</collection><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saikia, Bhaskar Jyoti</au><au>Das, Mandakini</au><au>Sharma, Santanu Kumar</au><au>Sekhon, Gaganpreet Singh</au><au>Zomawia, Eric</au><au>Singh, Yanglem Mohen</au><au>Mahanta, Jagadish</au><au>Phukan, Rup Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of a p53 Codon 72 Gene Polymorphism with Environmental Factors and Risk of Lung Cancer: a Case Control Study in Mizoram and Manipur, a High Incidence Region in North East India</atitle><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle><addtitle>Asian Pacific journal of cancer prevention : APJCP</addtitle><date>2014</date><risdate>2014</risdate><volume>15</volume><issue>24</issue><spage>10653</spage><epage>10658</epage><pages>10653-10658</pages><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>Background: A very high incidence of lung cancer is observed in Mizoram and Manipur, North East India. We conducted a population based case control study to establish associations of p53 codon 72 polymorphisms and interactions with environmental factors for this high incidence. Material and Methods: A total of 272 lung cancer cases and 544 controls matched for age (${\pm}5years$), sex and ethnicity were collected and p53 codon 72 polymorphism genotypes were analyzed using a polymerase chain based restriction fragment length polymorphism assay. We used conditional multiple logistic regression analysis to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: p53 Pro/Pro genotype was significantly associated with increased risk of lung cancer in the study population (adjusted OR=2.14, CI=1.35-3.38, p=0.001). Interactions of the p53 Pro/Pro genotype with exposure to wood smoke (adjusted OR=3.60, CI=1.85-6.98, p<0.001) and cooking oil fumes (adjusted OR=3.27, CI=1.55-6.87, p=0.002), betel quid chewing (adjusted OR=3.85, CI=1.96-7.55, p<0.001), tobacco smoking (adjusted OR=4.42, CI=2.27-8.63, p<0.001) and alcohol consumption (adjusted OR=3.31, CI=1.10-10.03, p=0.034) were significant regarding the increased risk of lung cancer in the study population. Conclusions: The present study provided preliminary evidence that a p53 codon 72 polymorphism may effect lung cancer risk in the study population, interacting synergistically with environmental factors.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Association of a p53 Codon 72 Gene Polymorphism with Environmental Factors and Risk of Lung Cancer: a Case Control Study in Mizoram and Manipur, a High Incidence Region in North East India |
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