MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current kno...

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Veröffentlicht in:Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 (18), p.7489-7497
Hauptverfasser: Kavitha, Nowroji, Vijayarathna, Soundararajan, Jothy, Subramanion Lachumy, Oon, Chern Ein, Chen, Yeng, Kanwar, Jagat Rakesh, Sasidharan, Sreenivasan
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container_issue 18
container_start_page 7489
container_title Asian Pacific journal of cancer prevention : APJCP
container_volume 15
creator Kavitha, Nowroji
Vijayarathna, Soundararajan
Jothy, Subramanion Lachumy
Oon, Chern Ein
Chen, Yeng
Kanwar, Jagat Rakesh
Sasidharan, Sreenivasan
description MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.
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title MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis
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