Efficient Enantioselective Synthesis of (R)-[3, 5-Bis (trifluoromethyl) phenyl] Ethanol by Leifsonia xyli CCTCC M 2010241 Using Isopropanol as Co-Substrate

(R)-[3,5-Bis(trifluoromethyl)phenyl] ethanol is a key chiral intermediate for the synthesis of aprepitant. In this paper, an efficient synthetic process for (R)-[3,5- bis(trifluoromethyl)phenyl] ethanol was developed via the asymmetric reduction of 3,5-bis(trifluoromethyl) acetophenone, catalyzed by...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2013-03, Vol.23 (3), p.343-350
Hauptverfasser:	Ouyang, Qi, Wang, Pu, Huang, Jin, Cai, Jinbo, He, Junyao
Format:	Artikel
Sprache:	kor
Schlagworte:	3 5-bis acetophenone co-enzyme regeneration enantioselective reduction Leifsonia xyli phenyl] ethanol R- trifluoromethyl
Online-Zugang:	Volltext
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