Effect of Cordycepin on the Expression of the Inflammatory Cytokines TNF-alpha, IL-6, and IL-17A in C57BL/6 Mice
Culture supernatants of splenocytes from C57BL/6 mice were exposed to 0.3, 1.0, and 3.0 μg/ml cordycepin plus 3.0 μg/ml lipopolysaccharide (LPS) to investigate the effects of cordycepin (3`-deoxyadenosine) on the production of inflammatory cytokines. Co-administration of 3.0 μg/ml cordycepin with LP...
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| Veröffentlicht in: | Journal of microbiology and biotechnology 2013-02, Vol.23 (2), p.156-160 |
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| container_title | Journal of microbiology and biotechnology |
| container_volume | 23 |
| creator | Seo, Min Jeong Kim, Min Jeong Lee, Hye Hyeon Park, Jeong Uck Kang, Byoung Won Kim, Gi-Young Rhu, En Ju Kim, Jung-In Kim, Kwang Hyuk Jeong, Yong Kee |
| description | Culture supernatants of splenocytes from C57BL/6 mice were exposed to 0.3, 1.0, and 3.0 μg/ml cordycepin plus 3.0 μg/ml lipopolysaccharide (LPS) to investigate the effects of cordycepin (3`-deoxyadenosine) on the production of inflammatory cytokines. Co-administration of 3.0 μg/ml cordycepin with LPS in cultured murine spleen cells significantly diminished the expression of the inflammatory cytokines tumor necrosis factor-α and interleukin-6 (IL-6) in a time-dependent manner. Expression of the inflammatory cytokine IL-17A was substantially down-regulated in a time- dependent manner at all cordycepin concentrations. These findings suggest that cordycepin down-regulates the immediate hypersensitivity reaction stimulated by LPS. |
| format | Article |
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Co-administration of 3.0 μg/ml cordycepin with LPS in cultured murine spleen cells significantly diminished the expression of the inflammatory cytokines tumor necrosis factor-α and interleukin-6 (IL-6) in a time-dependent manner. Expression of the inflammatory cytokine IL-17A was substantially down-regulated in a time- dependent manner at all cordycepin concentrations. 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Co-administration of 3.0 μg/ml cordycepin with LPS in cultured murine spleen cells significantly diminished the expression of the inflammatory cytokines tumor necrosis factor-α and interleukin-6 (IL-6) in a time-dependent manner. Expression of the inflammatory cytokine IL-17A was substantially down-regulated in a time- dependent manner at all cordycepin concentrations. 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Co-administration of 3.0 μg/ml cordycepin with LPS in cultured murine spleen cells significantly diminished the expression of the inflammatory cytokines tumor necrosis factor-α and interleukin-6 (IL-6) in a time-dependent manner. Expression of the inflammatory cytokine IL-17A was substantially down-regulated in a time- dependent manner at all cordycepin concentrations. These findings suggest that cordycepin down-regulates the immediate hypersensitivity reaction stimulated by LPS.</abstract><pub>한국미생물생명공학회</pub><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of microbiology and biotechnology, 2013-02, Vol.23 (2), p.156-160 |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Cordycepin IL-17A IL-6 splenocytes TNF-α |
| title | Effect of Cordycepin on the Expression of the Inflammatory Cytokines TNF-alpha, IL-6, and IL-17A in C57BL/6 Mice |
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