Hair Growth Promoting Effect of Essence Manufactured with Products Fermented by Lactobacillus rhamnosus and Backryeoncho (Opuntia ficus-indica var. sarboten) Fruits in Mice

Hair loss is a clinical problem that is becoming more common in the world but it is generally poorly controlled and more effective treatments are required. In this study, we evaluated the hair growth promoting effect of essence manufactured with products fermented by backryeoncho (Opuntia ficus-indica var. sarboten) fruits and Lactobacillus rhamnosus on hair growth in mice. The bacterial number after fermentation always remained higher than 6 log CFU/mL and the pH of those ranged from 4 to 6. Mice topically applied with 0.1 mL essence at once daily for 8 days after shaving furs of their back showed more significant hair growth promoting effect than that of minoxidil. Body weight and food intake of all groups didn't show significant difference. Furthermore, histological evaluation showed that the essence containing fermented products markedly increased the depth and size of the hair follicles, as compared to the minoxidil.