Neuroprotective Compounds Isolated from the Methanolic Extract of Lonicera japonica

Neuroprotective Compounds Isolated from the Methanolic Extract of Lonicera japonica

A $CH_3Cl$ extract from the flower of Lonicera japonica (Lauraceae) significantly protected primary cultures of rat cortical cells injured by the excitotoxic amino acid, L-glutamate. Loganin (1), secoxyloganin (2), caffeic acid (3) rutin (4), hyperoside (5), quercetin-3-O-glucoside (6), lonicerin (7...

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Veröffentlicht in:Natural product sciences 2011, Vol.17 (3), p.221-224
Hauptverfasser: Weon, Jin-Bae, Yang, Hye-Jin, Lee, Bo-Hyoung, Yun, Bo-Ra, Choong, Je-Ma
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creator Weon, Jin-Bae
Yang, Hye-Jin
Lee, Bo-Hyoung
Yun, Bo-Ra
Choong, Je-Ma
description A $CH_3Cl$ extract from the flower of Lonicera japonica (Lauraceae) significantly protected primary cultures of rat cortical cells injured by the excitotoxic amino acid, L-glutamate. Loganin (1), secoxyloganin (2), caffeic acid (3) rutin (4), hyperoside (5), quercetin-3-O-glucoside (6), lonicerin (7), kaempferol-3-O-rutinoside (8), luteolin-7-O-b-D-glucopyranoside (9), quercetin (10) and luteolin (11) were isolated by bioactivity-guided fractionation from the $CH_3Cl$ fraction and further separated using chromatographic techniques. Caffeic acid, lonicerin, kaempferol-3-O-rutinoside, quercetin and luteolin had significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at concentrations ranging from $0.1{\mu}M$ to $10.0\;{\mu}M$.
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title Neuroprotective Compounds Isolated from the Methanolic Extract of Lonicera japonica
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