A Blood-brain Barrier Permeable Derivative of 5-Fluorouracil: Preparation, Intracellular Localization, and Mouse Tissue Distribution

5-Fluorouracil (5-FU), an anticancer agent was covalently attached to the recently developed sorbitol-based G8 transporter, and the conjugate (7) with FITC was found to have an affinity toward mitochondria and to readily cross BBB to gain an entry into mouse brain. Measured by $IC_{50}$, the conjuga...

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Veröffentlicht in:	Bulletin of the Korean Chemical Society 2011, Vol.32 (3), p.873-879
Hauptverfasser:	Im, Jung-Kyun, Biswas, Goutam, Kim, Wan-Il, Kim, Kyong-Tai, Chung, Sung-Kee
Format:	Artikel
Sprache:	kor
Online-Zugang:	Volltext
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