Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide

Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide

The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic ${\beta}$-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose...

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Veröffentlicht in:Molecules and cells 2010, Vol.29 (4), p.349-354
Hauptverfasser: Lee, Byung-Ryong, Lee, Yeom-Pyo, Kim, Dae-Won, Song, Ha-Yong, Yoo, Ki-Yeon, Won, Moo-Ho, Kang, Tae-Cheon, Lee, Kwang-Jae, Kim, Kyung-Hee, Joo, Jin-Ho, Ham, Hun-Ju, Hur, Jang-Hyun, Cho, Sung-Woo, Han, Kyu-Hyung, Lee, Kil-Soo, Park, Jin-Seu, Eum, Won-Sik, Choi, Soo-Young
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container_end_page 354
container_issue 4
container_start_page 349
container_title Molecules and cells
container_volume 29
creator Lee, Byung-Ryong
Lee, Yeom-Pyo
Kim, Dae-Won
Song, Ha-Yong
Yoo, Ki-Yeon
Won, Moo-Ho
Kang, Tae-Cheon
Lee, Kwang-Jae
Kim, Kyung-Hee
Joo, Jin-Ho
Ham, Hun-Ju
Hur, Jang-Hyun
Cho, Sung-Woo
Han, Kyu-Hyung
Lee, Kil-Soo
Park, Jin-Seu
Eum, Won-Sik
Choi, Soo-Young
description The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic ${\beta}$-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic ${\beta}$-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.
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title Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide
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