Inhibition of Aldose Reductase from Rat Lenses by Methanol Extracts from Korean Folk Plants

Inhibition of Aldose Reductase from Rat Lenses by Methanol Extracts from Korean Folk Plants

The inhibition of rat lens aldose reductase (AR) in vitro using methanol extracts from Korean folk plants was investigated. Among them, the extracts of Saussurea grandifolia and Rumex crispus showed highest inhibition of AR. $IC_{50}$ values of the extracts from S. grandifolia and R. crispus were de...

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Veröffentlicht in:Natural product sciences 2010, Vol.16 (4), p.285-290
Hauptverfasser: Kim, Hye-Min, Mok, So-Youn, Lee, Jeong-Min, Cho, Eun-Ju, Choi, Kyung, Ku, Ja-Jung, Park, Kwang-Woo, Lee, Sang-Hyun
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container_issue 4
container_start_page 285
container_title Natural product sciences
container_volume 16
creator Kim, Hye-Min
Mok, So-Youn
Lee, Jeong-Min
Cho, Eun-Ju
Choi, Kyung
Ku, Ja-Jung
Park, Kwang-Woo
Lee, Sang-Hyun
description The inhibition of rat lens aldose reductase (AR) in vitro using methanol extracts from Korean folk plants was investigated. Among them, the extracts of Saussurea grandifolia and Rumex crispus showed highest inhibition of AR. $IC_{50}$ values of the extracts from S. grandifolia and R. crispus were demonstrated 0.07 and 0.05 mg/ml, respectively. Korean folk plants such as S. grandifolia and R. crispus has a possibility of new natural resources for the inhibition of AR.
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title Inhibition of Aldose Reductase from Rat Lenses by Methanol Extracts from Korean Folk Plants
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