ICR 마우스를 이용하여 사군자탕(四君子湯)의 급성 독성에 관한 연구

ICR 마우스를 이용하여 사군자탕(四君子湯)의 급성 독성에 관한 연구

Objectives : The purpose of this study was to investigate acute toxicity of orally-treated Sagunja-tang(Sijunzi-tang) in ICR mice. Methods : In this study, we investigated the acute toxicity of water-extracted Sagunja-tang(Sijunzi-tang). Twenty-five mice completed 14 days of oral Sagunja-tang(Sijunz...

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Veröffentlicht in:大韓韓醫學會誌 2007, Vol.28 (2), p.200-204
Hauptverfasser: 마진열, 황대선, 유영법, 하혜경, 신현규, Ma, Jin-Yeul, Huang, Dae-Sun, Yu, Young-Beob, Ha, Hye-Kyung, Shin, Hyun-Kyoo
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container_end_page 204
container_issue 2
container_start_page 200
container_title 大韓韓醫學會誌
container_volume 28
creator 마진열
황대선
유영법
하혜경
신현규
Ma, Jin-Yeul
Huang, Dae-Sun
Yu, Young-Beob
Ha, Hye-Kyung
Shin, Hyun-Kyoo
description Objectives : The purpose of this study was to investigate acute toxicity of orally-treated Sagunja-tang(Sijunzi-tang) in ICR mice. Methods : In this study, we investigated the acute toxicity of water-extracted Sagunja-tang(Sijunzi-tang). Twenty-five mice completed 14 days of oral Sagunja-tang(Sijunzi-tang) at respective doses of 0 (control group), 2560, 3200, 4000 and 5000 mg/kg. Results : We observed survival rates, clinical signs of male ICR mice with acute toxicity, change of body weight and autopsy. Conclusions : Compared with the control group, we could not find any toxic alteration in anytreated groups (2560, 3200, 4000 and 5000mg/kg). LD50 of Sagunja-tang(Sijunzi-tang) was over 5000 mg/kg and it is very safe for ICR mice.
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