살모넬라 세포외막단백질 혼합백신을 이용한 돼지 및 닭에서의 살모넬라균감염증 방어효과

We investigated the safety, immunogenicity and protectivity of mix-crude outer membrane protein (cOMP) vaccine against salmonellosis in animals. The mix-cOMP vaccine was extracted from Salmonella enterica serovar Typhimurium (ST) and Salmonella enterica serovar Enteritidis (SE) and Salmonella enteri...

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Veröffentlicht in:Taehan Suŭi Hakhoe chi 2007, Vol.47 (2), p.147-155
Hauptverfasser: 이희수, 임숙경, 조윤상, 주이석, 김재학, 김종만, Lee, Hee-Soo, Lim, Suk-Kyung, Cho, Yun-Sang, Joo, Yi-Seok, Kim, Jae-Hak, Kim, Jong-Man
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container_issue 2
container_start_page 147
container_title Taehan Suŭi Hakhoe chi
container_volume 47
creator 이희수
임숙경
조윤상
주이석
김재학
김종만
Lee, Hee-Soo
Lim, Suk-Kyung
Cho, Yun-Sang
Joo, Yi-Seok
Kim, Jae-Hak
Kim, Jong-Man
description We investigated the safety, immunogenicity and protectivity of mix-crude outer membrane protein (cOMP) vaccine against salmonellosis in animals. The mix-cOMP vaccine was extracted from Salmonella enterica serovar Typhimurium (ST) and Salmonella enterica serovar Enteritidis (SE) and Salmonella enterica serovar Braenderup (SB) isolated from pigs. The mix-cOMP vaccine gave significantly higher antibody response than ST-bacterin and ST-cOMP vaccine in guinea pigs. The survival rates of mix-cOMP vaccinated groups showed significantly higher (100%) than those (0-20%) of unvaccinated control group, challenged with 3 species of Salmonella (ST, SE and SB) in mice. Vaccinated groups in pigs showed reduction of clinical signs, increase of average weight gains, decrease of bacterial recovery rates, compared with unvaccinated groups. Especially, the survival rates (100%) of vaccinated groups in chickens showed higher than that (0%) of unvaccinated group. Based on these results, we suggest that the mix-cOMP Salmonella vaccine developed in this study will be effective for the protection against Salmonellosis caused by the various serotypes Salmonella species in animals.
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title 살모넬라 세포외막단백질 혼합백신을 이용한 돼지 및 닭에서의 살모넬라균감염증 방어효과
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