심장수술 시 황산마그네슘 투여의 임상효과
Background: Hypomagnesemia is a common complication after cardiac surgery with cardiopulmonary bypass. The purpose of this study was to assess the clinical beneficial effect of administration of magnesium sulfate in cardiac surgery. Material and Method: Thirty five patients scheduled for elective ca...
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| Veröffentlicht in: | Taehan Hyungbu Oekwa Hakhoe chi 2006, Vol.39 (5), p.366-375 |
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| creator | 방정희 문성민 김시호 조광조 최필조 우종수 Bang Jung-Heui Moon Seong-Min Kim Si-Ho Cho Kwang-Jo Choi Pil-Jo Woo Jong-Su |
| description | Background: Hypomagnesemia is a common complication after cardiac surgery with cardiopulmonary bypass. The purpose of this study was to assess the clinical beneficial effect of administration of magnesium sulfate in cardiac surgery. Material and Method: Thirty five patients scheduled for elective cardiac surgery were randomly assigned to magnesium group (n=20) which received magnesium sulfate in priming solution (1 g) and cardioplegic solution (1 g) or control group (n=15) which did not receive it. Arterial blood samples were drawn for measuring $Mg^{++}$ and electrolytes contents, blood gas analysis, CBC, total protein, albumin, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, tumor necrosis factor-${\alpha}$ $(TNF-{\alpha})$, interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase(LDH), troponin-1 (TNI), prothrombin time (PT) and activated pratial thromboplastin time level (aPTT). Venous blood samples were drawn before and after the operation for measuring activated clotting time level (ACT). Result: $Mg^{++}$ levels in magensium group were higher than those of control group at intraoperative and post-operative periods (p |
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| fullrecord | <record><control><sourceid>kisti</sourceid><recordid>TN_cdi_kisti_ndsl_JAKO200624717979154</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JAKO200624717979154</sourcerecordid><originalsourceid>FETCH-kisti_ndsl_JAKO2006247179791543</originalsourceid><addsrcrecordid>eNpjYeA0MDYw1DWyMLXkYOAtLs5MMjA2MzK3MDU15mSwetO95s28pW86ZrzpWKDwpnuOwtuZK980bXi9vOPV9h2vW5a86Zqh8LZjzZvpa97MnaHwZl7Lm-bGt7NWvNq8h4eBNS0xpziVF0pzM6i6uYY4e-hmZxaXZMbnpRTnxHs5evsbGRiYGZmYG5pbmlsampoYE6sOAL0SRlE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>심장수술 시 황산마그네슘 투여의 임상효과</title><source>KoreaMed Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>방정희 ; 문성민 ; 김시호 ; 조광조 ; 최필조 ; 우종수 ; Bang Jung-Heui ; Moon Seong-Min ; Kim Si-Ho ; Cho Kwang-Jo ; Choi Pil-Jo ; Woo Jong-Su</creator><creatorcontrib>방정희 ; 문성민 ; 김시호 ; 조광조 ; 최필조 ; 우종수 ; Bang Jung-Heui ; Moon Seong-Min ; Kim Si-Ho ; Cho Kwang-Jo ; Choi Pil-Jo ; Woo Jong-Su</creatorcontrib><description>Background: Hypomagnesemia is a common complication after cardiac surgery with cardiopulmonary bypass. The purpose of this study was to assess the clinical beneficial effect of administration of magnesium sulfate in cardiac surgery. Material and Method: Thirty five patients scheduled for elective cardiac surgery were randomly assigned to magnesium group (n=20) which received magnesium sulfate in priming solution (1 g) and cardioplegic solution (1 g) or control group (n=15) which did not receive it. Arterial blood samples were drawn for measuring $Mg^{++}$ and electrolytes contents, blood gas analysis, CBC, total protein, albumin, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, tumor necrosis factor-${\alpha}$ $(TNF-{\alpha})$, interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase(LDH), troponin-1 (TNI), prothrombin time (PT) and activated pratial thromboplastin time level (aPTT). Venous blood samples were drawn before and after the operation for measuring activated clotting time level (ACT). Result: $Mg^{++}$ levels in magensium group were higher than those of control group at intraoperative and post-operative periods (p<0.05). dysrhythmias were lower in magnesium group (8 cases out of 17 patients, 46.4%) than in control group (10 cases out of 10, 100%, p=0.050). Conclusion: These results showed that administration of low dose magnesium sulfate during cardiac surgery prevented hypomagnesemia and lowered incidence of dysrhythmia. 배경: 심폐바이패스를 이용한 심장수술에 따른 혈중 마그네슘 결핍 현상은 흔히 발생하는 합병중으로 이 연구의 목적은 심장수술시 인위적으로 첨가한 황산마그네슘의 유익한 임상 효과를 규명함에 있다. 대상 및 방법: 심폐바이패스를 이용하여 심장수술을 시행하기로 예정된 환자들 35명을 무작위로 황산마그네슘 투여군(n=15)과 투여하지 않은 군(n=20)으로 분류한 뒤 마그네슘군은 심폐기 충전액에 황산마그네슘 1g과 심정지액에 황산마그네슘 1g을 각각 첨가하였다. 요골 동맥으로부터 혈액을 채취하여 $Mg^{++}$ 농도, 전해질농도, 동맥혈액 가스분석, 혈액학적 분석, 혈청 총 단백 농도와 albumin 농도, blood urea nitrogen (BUN), creatinine, alanine amino transferase (ALT), aspartate aminotransferase (AST), total bilirubin 농도, tumor nerosis factor-${\alpha}$ $(TNF-{\alpha})$, interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), troponin-I (TNI) 농도, prothrombin time (PT)과 activated partial thromboplastin time (aPTT) 등도 측정하였다. 또한 수술 전과 후 정맥 혈액을 채취하여 activated clotting time (ACT)을 측정하였다. 결과: $Mg^{++}$ 농도는 수술 동안 및 후 시기에 마그네슘군이 대조군보다 유의하게 높게 유지되었다(p<0.05). 수술 전 부정맥이 없었던 환자들(대조군=10명, 마그네슘군=17명) 중 수술 후 부정맥 발생 수는 대조군이 10명(100%) 마그네슘군이 8명(46.4%)으로 마그네슘군이 대조군보다 유의하게 적었다(p=0.050). 결론: 심장수술 시 저용량의 황산마그네슘의 투여는 수술 중과 수술 후 저마그네슘 혈증의 예방과 부정맥의 빈도를 낮춰줄 것으로 생각한다.</description><identifier>ISSN: 0301-2859</identifier><language>kor</language><ispartof>Taehan Hyungbu Oekwa Hakhoe chi, 2006, Vol.39 (5), p.366-375</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,4009</link.rule.ids></links><search><creatorcontrib>방정희</creatorcontrib><creatorcontrib>문성민</creatorcontrib><creatorcontrib>김시호</creatorcontrib><creatorcontrib>조광조</creatorcontrib><creatorcontrib>최필조</creatorcontrib><creatorcontrib>우종수</creatorcontrib><creatorcontrib>Bang Jung-Heui</creatorcontrib><creatorcontrib>Moon Seong-Min</creatorcontrib><creatorcontrib>Kim Si-Ho</creatorcontrib><creatorcontrib>Cho Kwang-Jo</creatorcontrib><creatorcontrib>Choi Pil-Jo</creatorcontrib><creatorcontrib>Woo Jong-Su</creatorcontrib><title>심장수술 시 황산마그네슘 투여의 임상효과</title><title>Taehan Hyungbu Oekwa Hakhoe chi</title><addtitle>The Korean journal of thoracic and cardiovascular surgery</addtitle><description>Background: Hypomagnesemia is a common complication after cardiac surgery with cardiopulmonary bypass. The purpose of this study was to assess the clinical beneficial effect of administration of magnesium sulfate in cardiac surgery. Material and Method: Thirty five patients scheduled for elective cardiac surgery were randomly assigned to magnesium group (n=20) which received magnesium sulfate in priming solution (1 g) and cardioplegic solution (1 g) or control group (n=15) which did not receive it. Arterial blood samples were drawn for measuring $Mg^{++}$ and electrolytes contents, blood gas analysis, CBC, total protein, albumin, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, tumor necrosis factor-${\alpha}$ $(TNF-{\alpha})$, interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase(LDH), troponin-1 (TNI), prothrombin time (PT) and activated pratial thromboplastin time level (aPTT). Venous blood samples were drawn before and after the operation for measuring activated clotting time level (ACT). Result: $Mg^{++}$ levels in magensium group were higher than those of control group at intraoperative and post-operative periods (p<0.05). dysrhythmias were lower in magnesium group (8 cases out of 17 patients, 46.4%) than in control group (10 cases out of 10, 100%, p=0.050). Conclusion: These results showed that administration of low dose magnesium sulfate during cardiac surgery prevented hypomagnesemia and lowered incidence of dysrhythmia. 배경: 심폐바이패스를 이용한 심장수술에 따른 혈중 마그네슘 결핍 현상은 흔히 발생하는 합병중으로 이 연구의 목적은 심장수술시 인위적으로 첨가한 황산마그네슘의 유익한 임상 효과를 규명함에 있다. 대상 및 방법: 심폐바이패스를 이용하여 심장수술을 시행하기로 예정된 환자들 35명을 무작위로 황산마그네슘 투여군(n=15)과 투여하지 않은 군(n=20)으로 분류한 뒤 마그네슘군은 심폐기 충전액에 황산마그네슘 1g과 심정지액에 황산마그네슘 1g을 각각 첨가하였다. 요골 동맥으로부터 혈액을 채취하여 $Mg^{++}$ 농도, 전해질농도, 동맥혈액 가스분석, 혈액학적 분석, 혈청 총 단백 농도와 albumin 농도, blood urea nitrogen (BUN), creatinine, alanine amino transferase (ALT), aspartate aminotransferase (AST), total bilirubin 농도, tumor nerosis factor-${\alpha}$ $(TNF-{\alpha})$, interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), troponin-I (TNI) 농도, prothrombin time (PT)과 activated partial thromboplastin time (aPTT) 등도 측정하였다. 또한 수술 전과 후 정맥 혈액을 채취하여 activated clotting time (ACT)을 측정하였다. 결과: $Mg^{++}$ 농도는 수술 동안 및 후 시기에 마그네슘군이 대조군보다 유의하게 높게 유지되었다(p<0.05). 수술 전 부정맥이 없었던 환자들(대조군=10명, 마그네슘군=17명) 중 수술 후 부정맥 발생 수는 대조군이 10명(100%) 마그네슘군이 8명(46.4%)으로 마그네슘군이 대조군보다 유의하게 적었다(p=0.050). 결론: 심장수술 시 저용량의 황산마그네슘의 투여는 수술 중과 수술 후 저마그네슘 혈증의 예방과 부정맥의 빈도를 낮춰줄 것으로 생각한다.</description><issn>0301-2859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>JDI</sourceid><recordid>eNpjYeA0MDYw1DWyMLXkYOAtLs5MMjA2MzK3MDU15mSwetO95s28pW86ZrzpWKDwpnuOwtuZK980bXi9vOPV9h2vW5a86Zqh8LZjzZvpa97MnaHwZl7Lm-bGt7NWvNq8h4eBNS0xpziVF0pzM6i6uYY4e-hmZxaXZMbnpRTnxHs5evsbGRiYGZmYG5pbmlsampoYE6sOAL0SRlE</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>방정희</creator><creator>문성민</creator><creator>김시호</creator><creator>조광조</creator><creator>최필조</creator><creator>우종수</creator><creator>Bang Jung-Heui</creator><creator>Moon Seong-Min</creator><creator>Kim Si-Ho</creator><creator>Cho Kwang-Jo</creator><creator>Choi Pil-Jo</creator><creator>Woo Jong-Su</creator><scope>JDI</scope></search><sort><creationdate>2006</creationdate><title>심장수술 시 황산마그네슘 투여의 임상효과</title><author>방정희 ; 문성민 ; 김시호 ; 조광조 ; 최필조 ; 우종수 ; Bang Jung-Heui ; Moon Seong-Min ; Kim Si-Ho ; Cho Kwang-Jo ; Choi Pil-Jo ; Woo Jong-Su</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kisti_ndsl_JAKO2006247179791543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2006</creationdate><toplevel>online_resources</toplevel><creatorcontrib>방정희</creatorcontrib><creatorcontrib>문성민</creatorcontrib><creatorcontrib>김시호</creatorcontrib><creatorcontrib>조광조</creatorcontrib><creatorcontrib>최필조</creatorcontrib><creatorcontrib>우종수</creatorcontrib><creatorcontrib>Bang Jung-Heui</creatorcontrib><creatorcontrib>Moon Seong-Min</creatorcontrib><creatorcontrib>Kim Si-Ho</creatorcontrib><creatorcontrib>Cho Kwang-Jo</creatorcontrib><creatorcontrib>Choi Pil-Jo</creatorcontrib><creatorcontrib>Woo Jong-Su</creatorcontrib><collection>KoreaScience</collection><jtitle>Taehan Hyungbu Oekwa Hakhoe chi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>방정희</au><au>문성민</au><au>김시호</au><au>조광조</au><au>최필조</au><au>우종수</au><au>Bang Jung-Heui</au><au>Moon Seong-Min</au><au>Kim Si-Ho</au><au>Cho Kwang-Jo</au><au>Choi Pil-Jo</au><au>Woo Jong-Su</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>심장수술 시 황산마그네슘 투여의 임상효과</atitle><jtitle>Taehan Hyungbu Oekwa Hakhoe chi</jtitle><addtitle>The Korean journal of thoracic and cardiovascular surgery</addtitle><date>2006</date><risdate>2006</risdate><volume>39</volume><issue>5</issue><spage>366</spage><epage>375</epage><pages>366-375</pages><issn>0301-2859</issn><abstract>Background: Hypomagnesemia is a common complication after cardiac surgery with cardiopulmonary bypass. The purpose of this study was to assess the clinical beneficial effect of administration of magnesium sulfate in cardiac surgery. Material and Method: Thirty five patients scheduled for elective cardiac surgery were randomly assigned to magnesium group (n=20) which received magnesium sulfate in priming solution (1 g) and cardioplegic solution (1 g) or control group (n=15) which did not receive it. Arterial blood samples were drawn for measuring $Mg^{++}$ and electrolytes contents, blood gas analysis, CBC, total protein, albumin, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, tumor necrosis factor-${\alpha}$ $(TNF-{\alpha})$, interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase(LDH), troponin-1 (TNI), prothrombin time (PT) and activated pratial thromboplastin time level (aPTT). Venous blood samples were drawn before and after the operation for measuring activated clotting time level (ACT). Result: $Mg^{++}$ levels in magensium group were higher than those of control group at intraoperative and post-operative periods (p<0.05). dysrhythmias were lower in magnesium group (8 cases out of 17 patients, 46.4%) than in control group (10 cases out of 10, 100%, p=0.050). Conclusion: These results showed that administration of low dose magnesium sulfate during cardiac surgery prevented hypomagnesemia and lowered incidence of dysrhythmia. 배경: 심폐바이패스를 이용한 심장수술에 따른 혈중 마그네슘 결핍 현상은 흔히 발생하는 합병중으로 이 연구의 목적은 심장수술시 인위적으로 첨가한 황산마그네슘의 유익한 임상 효과를 규명함에 있다. 대상 및 방법: 심폐바이패스를 이용하여 심장수술을 시행하기로 예정된 환자들 35명을 무작위로 황산마그네슘 투여군(n=15)과 투여하지 않은 군(n=20)으로 분류한 뒤 마그네슘군은 심폐기 충전액에 황산마그네슘 1g과 심정지액에 황산마그네슘 1g을 각각 첨가하였다. 요골 동맥으로부터 혈액을 채취하여 $Mg^{++}$ 농도, 전해질농도, 동맥혈액 가스분석, 혈액학적 분석, 혈청 총 단백 농도와 albumin 농도, blood urea nitrogen (BUN), creatinine, alanine amino transferase (ALT), aspartate aminotransferase (AST), total bilirubin 농도, tumor nerosis factor-${\alpha}$ $(TNF-{\alpha})$, interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), troponin-I (TNI) 농도, prothrombin time (PT)과 activated partial thromboplastin time (aPTT) 등도 측정하였다. 또한 수술 전과 후 정맥 혈액을 채취하여 activated clotting time (ACT)을 측정하였다. 결과: $Mg^{++}$ 농도는 수술 동안 및 후 시기에 마그네슘군이 대조군보다 유의하게 높게 유지되었다(p<0.05). 수술 전 부정맥이 없었던 환자들(대조군=10명, 마그네슘군=17명) 중 수술 후 부정맥 발생 수는 대조군이 10명(100%) 마그네슘군이 8명(46.4%)으로 마그네슘군이 대조군보다 유의하게 적었다(p=0.050). 결론: 심장수술 시 저용량의 황산마그네슘의 투여는 수술 중과 수술 후 저마그네슘 혈증의 예방과 부정맥의 빈도를 낮춰줄 것으로 생각한다.</abstract><oa>free_for_read</oa></addata></record> |
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| title | 심장수술 시 황산마그네슘 투여의 임상효과 |
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