Evodiamine의 Monoamine Oxidase 활성 저해작용
The effects of evodiamine on monoamine oxidase (MAO) activity were investigated. MAO was purified from mouse brain and the $K_m\;and\;V_{max}$ values of MAO were $78.5{\pm}5.28{\mu}M$ and $0.68{\pm}0.07$ nmol/min/mg protein, respectively (n=4). Evodiamine at $30-120{\mu}M$ showed an inhibitory effec...
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| Veröffentlicht in: | 생약학회지 2006, Vol.37 (4), p.320-327 |
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| container_title | 생약학회지 |
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| creator | 이상선(Sang Seon Lee) 황방연(Bang Yeon Hwang) 노재섭(Jai Seup Ro) 이명구(Myung Koo Lee) |
| description | The effects of evodiamine on monoamine oxidase (MAO) activity were investigated. MAO was purified from mouse brain and the $K_m\;and\;V_{max}$ values of MAO were $78.5{\pm}5.28{\mu}M$ and $0.68{\pm}0.07$ nmol/min/mg protein, respectively (n=4). Evodiamine at $30-120{\mu}M$ showed an inhibitory effect on MAO activity using a substrate kynuramine with an $IC_{50}$ value of $104.2{\mu}M$ (n=4). Evodiamine also exhibited a non-competitive inhibition on MAO. The $K_i$ value for evodiamine was $72.5{\pm}10.8{\mu}M$ (n=4). These results suggest that evodiamine partially contributes to the regulation of monoamine content. |
| format | Article |
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| title | Evodiamine의 Monoamine Oxidase 활성 저해작용 |
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