Effects of Galhwahyejung-tang (GHT) on Protection for Alcohol-induced Liver Injury

Effects of Galhwahyejung-tang (GHT) on Protection for Alcohol-induced Liver Injury

Objective: The purpose of this study was to examine the protective efficacy of GHT on alcoholic liver injury. Methods: We measured the rate of alcohol oxidation, serum level of liver enzyme, lipid peroxidation level in liver tissue, and inflammatory related cytokine expressions in the liver. Results...

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Veröffentlicht in:大韓韓醫學會誌 2005, Vol.26 (1), p.76-84
Hauptverfasser: Ahn Tae-Kyu, Shin Jang-Woo, Cho Chong-Kwan, Cho Jung-Hyo, Yoo Hwa-Seung, Lee Yeon-Weol, Lee Nam-heon, Yun Dam-hee, Son Chang-Gue
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container_title 大韓韓醫學會誌
container_volume 26
creator Ahn Tae-Kyu
Shin Jang-Woo
Cho Chong-Kwan
Cho Jung-Hyo
Yoo Hwa-Seung
Lee Yeon-Weol
Lee Nam-heon
Yun Dam-hee
Son Chang-Gue
description Objective: The purpose of this study was to examine the protective efficacy of GHT on alcoholic liver injury. Methods: We measured the rate of alcohol oxidation, serum level of liver enzyme, lipid peroxidation level in liver tissue, and inflammatory related cytokine expressions in the liver. Results : GHT showed liver protective effects, lowered the levels of AST and LDH in serum and inhibited lipid peroxidation in liver tissue, and enhanced alcohol oxidation. GHT treatment up-regulated IL-10 in the liver, whereas it down­regulated $TNF-\alpha,\;TGF-\beta$, and Fas ligand. Conclusion : From these results, GHT is presumed to work in the liver in protective roles not through the pathway of alcohol metabolism but mainly by anti-inflammation activity in our model.
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title Effects of Galhwahyejung-tang (GHT) on Protection for Alcohol-induced Liver Injury
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