4,5-치환 3-alkoxy-6-allylthiopyridazine 유도체 합성
Through a modification of allicin structure a disagreeable odor and chemical instability of allicin can be improved. 3-Alkoxy-6-allylthiopyridazine derivatives exhibit a superior effect for prevention and treatment of hepatic diseases induced by carbon tetrachloride and aflatoxin B1 and for preventi...
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| Veröffentlicht in: | Yaghag-hoi-ji 2002-06, Vol.46 (3), p.155-160 |
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| Sprache: | kor |
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| container_issue | 3 |
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| container_title | Yaghag-hoi-ji |
| container_volume | 46 |
| creator | 권순경(Soon Kyoung Kwon) |
| description | Through a modification of allicin structure a disagreeable odor and chemical instability of allicin can be improved. 3-Alkoxy-6-allylthiopyridazine derivatives exhibit a superior effect for prevention and treatment of hepatic diseases induced by carbon tetrachloride and aflatoxin B1 and for prevention of human tissues from radiation. These compounds inhibit also efficiently SK-Hep-1 cell proliferation through induction of apoptosis. So another 4,5-mono- or di-substituted 3-alkyloxy-6-allylthiopyridazine derivatives were synthesized on purpose to find out SAR of allylthiopyridazine in hepatoprotective and hepatotherapeutic acitivitis and to develop more effective drug candidate. |
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| fulltext | fulltext |
| identifier | ISSN: 0377-9556 |
| ispartof | Yaghag-hoi-ji, 2002-06, Vol.46 (3), p.155-160 |
| issn | 0377-9556 2383-9457 |
| language | kor |
| recordid | cdi_kisti_ndsl_JAKO200211922261273 |
| source | Alma/SFX Local Collection |
| title | 4,5-치환 3-alkoxy-6-allylthiopyridazine 유도체 합성 |
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