Total Synthesis of a New 7-Deoxyidarubicinone Derivative through the Functionalization of an A-Ring Side Chain

Total Synthesis of a New 7-Deoxyidarubicinone Derivative through the Functionalization of an A-Ring Side Chain

A convenient total synthesis of a new 7-deoxyidarubicinone ivative21,the aglycon of the anticancer anti-biotic idarubicin analogue,is described.Keyfeatures of the synthesis are the Friedel-Crafts acylation and the functionalization of an A-ring si de chain. A synthon 14 for the A and B rings was pre...

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Veröffentlicht in:Bulletin of the Korean Chemical Society 2000, Vol.21 (8), p.774-778
Hauptverfasser: 고현경, 김완중, 유동진, 강현수, Rho, Young S, Go, Hyeon Gyeong, Kim, Wan Jung, Yu, Dong Jin, Gang, Hyeon Su
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Sprache:kor
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Zusammenfassung:A convenient total synthesis of a new 7-deoxyidarubicinone ivative21,the aglycon of the anticancer anti-biotic idarubicin analogue,is described.Keyfeatures of the synthesis are the Friedel-Crafts acylation and the functionalization of an A-ring si de chain. A synthon 14 for the A and B rings was prepared from intermediate 6 in five steps.
ISSN:0253-2964
1229-5949