면역글로부린 G 생성에 대한 아이오타-카라기난의 어쥬번트 효과
To investigate the effects of iota-carrageenan (CAR) and/or alum on the adjuvancity as well as the structural difference of oligosaccharide on the IgG2b in the adjuvant effect, C57BL/6 mice were immunized twice with fetuin as a model antigen. CAR alone showed no significant effect on induction of an...
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| Veröffentlicht in: | Yaghag-hoi-ji 2000-12, Vol.44 (6), p.588-594 |
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| container_title | Yaghag-hoi-ji |
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| creator | 구본웅(Bon Woong Koo) 이광재(Kwang Jae Lee) 김만석(Man Suk Kim) 김하형(Ha Hyung Kim) |
| description | To investigate the effects of iota-carrageenan (CAR) and/or alum on the adjuvancity as well as the structural difference of oligosaccharide on the IgG2b in the adjuvant effect, C57BL/6 mice were immunized twice with fetuin as a model antigen. CAR alone showed no significant effect on induction of antibody except IgG1. In contrast, Alum-CAR (after mixing of antigen-Alum, CAR adjuvant was prepared) and CAR-Alum (after formulation of antigen-CAR, Alum adjuvant was prepared) enhanced production of antibody, especially, IgG2b. After separation of IgG2b, changes of glycosylation were investigated using enzymelinked lectin assay. High affinity of IgG2b to N-acetylneuraminic acid, galactose and mannose-specific lectin were induced by CAR-Alum adjuvant, however, the affinity of IgG2b induced by CAR-Alum to GlcNAc and GalNAc-specific lectin were much less than that induced by Alum-CAR. |
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High affinity of IgG2b to N-acetylneuraminic acid, galactose and mannose-specific lectin were induced by CAR-Alum adjuvant, however, the affinity of IgG2b induced by CAR-Alum to GlcNAc and GalNAc-specific lectin were much less than that induced by Alum-CAR.</description><issn>0377-9556</issn><issn>2383-9457</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>JDI</sourceid><recordid>eNpNkM1Kw0AcxBdRsNS-Qy4eA5v9-ifHUrR-FHopXkM2zUJpMWB68RZsDyIevNQWaQ6CioJC1SAV-kTdzTsY0INzGRh-DMNsoAqhLrU9xmETVTAFsD3OxTaqJUlPYioIuEB5BZ3ol9xM39bLVN_P9VeqnxZW0zKjzIzfzfTG0tdpMZlbZjI2WW5mD8Uotc13rrPVernQF3OTzSxzm5vHV_1xWVwtreLuef252kFbKhgkUe3Pq6izv9dpHNitdvOwUW_ZfYHBJkIEnChgKlKy3NoFzmgkWSTLgHOPqjCgUjoqUExgj4TC4aBcwE6IuyBDWkW7v7X9XjLs-afdZOAf1Y_bBJeimLqu5wD1_nHnsYx9Gcf9MDodRmc-ww7GhGEGvDzkB149c5o</recordid><startdate>20001230</startdate><enddate>20001230</enddate><creator>구본웅(Bon Woong Koo)</creator><creator>이광재(Kwang Jae Lee)</creator><creator>김만석(Man Suk Kim)</creator><creator>김하형(Ha Hyung Kim)</creator><general>The Pharmaceutical Society Of Korea</general><general>대한약학회</general><scope>P5Y</scope><scope>SSSTE</scope><scope>JDI</scope></search><sort><creationdate>20001230</creationdate><title>면역글로부린 G 생성에 대한 아이오타-카라기난의 어쥬번트 효과</title><author>구본웅(Bon Woong Koo) ; 이광재(Kwang Jae Lee) ; 김만석(Man Suk Kim) ; 김하형(Ha Hyung Kim)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k607-266a52f74fefb945d7543eb4ebfef5593fca3bb1faf46092c6157f8701c0d7bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2000</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>구본웅(Bon Woong Koo)</creatorcontrib><creatorcontrib>이광재(Kwang Jae Lee)</creatorcontrib><creatorcontrib>김만석(Man Suk Kim)</creatorcontrib><creatorcontrib>김하형(Ha Hyung Kim)</creatorcontrib><collection>Kyobo Scholar (교보스콜라)</collection><collection>Scholar(스콜라)</collection><collection>KoreaScience</collection><jtitle>Yaghag-hoi-ji</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>구본웅(Bon Woong Koo)</au><au>이광재(Kwang Jae Lee)</au><au>김만석(Man Suk Kim)</au><au>김하형(Ha Hyung Kim)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>면역글로부린 G 생성에 대한 아이오타-카라기난의 어쥬번트 효과</atitle><jtitle>Yaghag-hoi-ji</jtitle><addtitle>Yakhak hoeji</addtitle><date>2000-12-30</date><risdate>2000</risdate><volume>44</volume><issue>6</issue><spage>588</spage><epage>594</epage><pages>588-594</pages><issn>0377-9556</issn><eissn>2383-9457</eissn><abstract>To investigate the effects of iota-carrageenan (CAR) and/or alum on the adjuvancity as well as the structural difference of oligosaccharide on the IgG2b in the adjuvant effect, C57BL/6 mice were immunized twice with fetuin as a model antigen. CAR alone showed no significant effect on induction of antibody except IgG1. In contrast, Alum-CAR (after mixing of antigen-Alum, CAR adjuvant was prepared) and CAR-Alum (after formulation of antigen-CAR, Alum adjuvant was prepared) enhanced production of antibody, especially, IgG2b. After separation of IgG2b, changes of glycosylation were investigated using enzymelinked lectin assay. High affinity of IgG2b to N-acetylneuraminic acid, galactose and mannose-specific lectin were induced by CAR-Alum adjuvant, however, the affinity of IgG2b induced by CAR-Alum to GlcNAc and GalNAc-specific lectin were much less than that induced by Alum-CAR.</abstract><pub>The Pharmaceutical Society Of Korea</pub><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0377-9556 |
| ispartof | Yaghag-hoi-ji, 2000-12, Vol.44 (6), p.588-594 |
| issn | 0377-9556 2383-9457 |
| language | kor |
| recordid | cdi_kisti_ndsl_JAKO200003038891739 |
| source | Alma/SFX Local Collection |
| title | 면역글로부린 G 생성에 대한 아이오타-카라기난의 어쥬번트 효과 |
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