L - NAME 에 의한 쥐의 발바닥에서 Freund's Complete Adjuvant 에 의해 유발된 통증 억제

Background: Effect of nitric oxide on the hyperalgesia induced by inflammation is controversial. We attempted to find out the peripheral effects of nitric oxide (NO) on hyperalgesia induced by Freund's eomplete adjuvant (FCA) induced inflammation. Methods: Male Sprague Dawley rats were divided into three groups; control, low dose NG-nitro- L-arginine methyl ester (L-NAME, 500 ug), high dose L-NAME (5 mg). Inflammation was induced by injecting 0.l ml of PCA intraplantarly, which shows typical hyperalgesia within twelve hours after injec- tion and maintamed for about one week. Drugs were injected 2 hours before, just before, and 3, 6, 9, 12 hours after the injection of FCA. Effect of L-NAME on hyperalgesia was assessed by measuring mechanical hyperalgesia and spontaneous pain for 3 days. Results: When injected at the site of inflammation, L-NAME caused dose dependent reduction of sponlaneous hyperalgesia. Mechanical hyperalgesia was also reduced by high dose L-NAME (p