기니픽과 마우스에서 HRccine(HFRS 바이러스 백신)의 항원성 시험

기니픽과 마우스에서 HRccine(HFRS 바이러스 백신)의 항원성 시험

A study on antigenicity of HRccine (formalin inactivated HFRS virus vaccine) was investigated in guinea pigs and mice. As a part of the safety evaluation of the HRccine, antigenicity tests were carried out according to the Estabilish Regulations of National Institute of Safety Research. In active sy...

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Veröffentlicht in:한국독성학회지 1995, Vol.11 (1), p.157-159
Hauptverfasser: 백영옥, 손정진, 안세헌, 김태성, 이상옥, 이영수, 조정식
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container_end_page 159
container_issue 1
container_start_page 157
container_title 한국독성학회지
container_volume 11
creator 백영옥
손정진
안세헌
김태성
이상옥
이영수
조정식
description A study on antigenicity of HRccine (formalin inactivated HFRS virus vaccine) was investigated in guinea pigs and mice. As a part of the safety evaluation of the HRccine, antigenicity tests were carried out according to the Estabilish Regulations of National Institute of Safety Research. In active systemic anaphylaxis (ASA) test no sign was detected when sensitized with up to 120 clinical dose and challenged with up to 1200 clinical dose in guinea pigs. In passive systemic anaphylaxis test guinea pigs showed no sign. In passive cutaneous anaphylaxis (PCA) test, HRccine specific IgE antibody was not detected when sensitized and challenged with up to 1200 clinical dose. Conclusively, there was no adverse antigenic potential at the clinical dose of 120 clinical dose alone and 120 clinical dose with Al(OH)3.
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title 기니픽과 마우스에서 HRccine(HFRS 바이러스 백신)의 항원성 시험
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