신규 Carbapenem 유도체 CRB 529, 535, 538, 545, 550의 시험관내 항균력 평가

The in vitro antibacterial activities of new carbapenem. CRB 529, 535, 538, 545 and 550 with meropenem and imipenem were compared. CRB 529. 535, 538, 545 and 550 proved to have a broad an tibacterial spectrum. Its in vitro activity against standard 20 strains was almost the same as that of imipenem...

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Veröffentlicht in:Yaghag-hoi-ji 1995-06, Vol.39 (3), p.215-222
Hauptverfasser: 민관기(Kwan Kee Min), 김준겸(Joon Kyum Kim), 이홍우(Hong Woo Lee), 김정우(Jeong Woo Kim)
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container_title Yaghag-hoi-ji
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creator 민관기(Kwan Kee Min)
김준겸(Joon Kyum Kim)
이홍우(Hong Woo Lee)
김정우(Jeong Woo Kim)
description The in vitro antibacterial activities of new carbapenem. CRB 529, 535, 538, 545 and 550 with meropenem and imipenem were compared. CRB 529. 535, 538, 545 and 550 proved to have a broad an tibacterial spectrum. Its in vitro activity against standard 20 strains was almost the same as that of imipenem and slightly higher than that of meropenem. However. against clinical isolated P. aeruginosa, CRB 529, 535, 538, 545 and 550 showed significantly higher activity than imipenem, and also CRB 529, 535, 538, 545 and 550 showed almost the same activity than imipenem and meropenem against 82 clinical isolated strains including S. aureus (MRSA), S. aureus (MSSA), E. faecalis, E. facium, E. coli, P. aeruginosa, K. pneumonia, P. mirabiris, P. stuartii, M. morganii, C. freundii, E. cloacae, S. marcescens and A. calcoaceticus var. anitratus. The stability of CRB 529, 535, 538, 545 and 550 against porcine renal dehydropeptidase-I(DHP-1) was 10 folds higher than that of imipenem and was 3 folds higher than that of meropenem.
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source Alma/SFX Local Collection
title 신규 Carbapenem 유도체 CRB 529, 535, 538, 545, 550의 시험관내 항균력 평가
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