수종의 생약이 PC12 Cells 중의 Catecholamines 생합성에 미치는 영향

수종의 생약이 PC12 Cells 중의 Catecholamines 생합성에 미치는 영향

MeOH extracts of eight herbal medicines were investigated for the effects on catecholamine biosynthesis and tyrosine hydroxylase (TH) activity in PC12 cells. Among them, the MeOH extracts of Polygalae Radix and Rehmaniae Radix showed 32 and 22% inhibition on the dopamine biosynthesis, respectively a...

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Veröffentlicht in:생약학회지 1995, Vol.26 (1), p.57-61
Hauptverfasser: 이명구(Myung Koo Lee), 황방연(Bang Yeon Hwang), 정은희(Eun Hee Jung), 이경순(Kyong Soon Lee), 김학성(Hack Seang Kim)
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container_title 생약학회지
container_volume 26
creator 이명구(Myung Koo Lee)
황방연(Bang Yeon Hwang)
정은희(Eun Hee Jung)
이경순(Kyong Soon Lee)
김학성(Hack Seang Kim)
description MeOH extracts of eight herbal medicines were investigated for the effects on catecholamine biosynthesis and tyrosine hydroxylase (TH) activity in PC12 cells. Among them, the MeOH extracts of Polygalae Radix and Rehmaniae Radix showed 32 and 22% inhibition on the dopamine biosynthesis, respectively at a concentration of $40{\mu}g/ml$ medium. But, the TH activity was reduced by the treatment of Polygalae Radix. These results suggest that Polygalae Radix has an inhibitory effect on the catecholamine biosynthesis by the reduction of TH activity in PC12 cells.
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title 수종의 생약이 PC12 Cells 중의 Catecholamines 생합성에 미치는 영향
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