1,4-디하드로피리딘 산류의 합성(II)
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(2'-methylthio)ethyl ester methyl iodide salt (7a) was hydrolyzed by treatment with NaOH in aquous EtOH solution to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid mono...
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| Veröffentlicht in: | Yaghag-hoi-ji 1989-08, Vol.33 (4), p.219-225 |
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| container_title | Yaghag-hoi-ji |
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| creator | 서정진(Jung Jin Suh) 홍유화(You Hwa Hong) |
| description | 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(2'-methylthio)ethyl ester methyl iodide salt (7a) was hydrolyzed by treatment with NaOH in aquous EtOH solution to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid mono methyl ester (2b) in 88% yield. By the same procedure, 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridinine-3,5-dicarboxylic acid 3-mono isopropyl ester (2c), 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2d), 2,6-dimethyl-4-(2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2e) and 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylic acid (2f) were obtained from the methyl iodide salts in 91-98% yield. |
| format | Article |
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By the same procedure, 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridinine-3,5-dicarboxylic acid 3-mono isopropyl ester (2c), 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2d), 2,6-dimethyl-4-(2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2e) and 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylic acid (2f) were obtained from the methyl iodide salts in 91-98% yield.</description><identifier>ISSN: 0377-9556</identifier><identifier>EISSN: 2383-9457</identifier><language>kor</language><publisher>The Pharmaceutical Society Of Korea</publisher><ispartof>Yaghag-hoi-ji, 1989-08, Vol.33 (4), p.219-225</ispartof><rights>COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881</link.rule.ids></links><search><creatorcontrib>서정진(Jung Jin Suh)</creatorcontrib><creatorcontrib>홍유화(You Hwa Hong)</creatorcontrib><title>1,4-디하드로피리딘 산류의 합성(II)</title><title>Yaghag-hoi-ji</title><addtitle>Yakhak hoeji</addtitle><description>2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(2'-methylthio)ethyl ester methyl iodide salt (7a) was hydrolyzed by treatment with NaOH in aquous EtOH solution to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid mono methyl ester (2b) in 88% yield. By the same procedure, 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridinine-3,5-dicarboxylic acid 3-mono isopropyl ester (2c), 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2d), 2,6-dimethyl-4-(2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2e) and 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylic acid (2f) were obtained from the methyl iodide salts in 91-98% yield.</description><issn>0377-9556</issn><issn>2383-9457</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>JDI</sourceid><recordid>eNpNjD1Lw0Achw9RMNR-hy6Cgid397_XsRRfooUu3UPucoGQ0oDp4ip-A1PIUAcHBcFBd7_RJd_BgA7CD55nePjtoYiBBmy4UPsoIqAUNkLIQzSu68ISkExpBSJC5_SM49A0_bYNT7vwsuub7_D2EZp20j18hte2e24n_fa9e_w6iePTI3SQp6vaj_84QsvLi-XsGs8XV_FsOselJAyDFESqVBjhWKZTn3kHVlOlOPOWUKEzwVNwzjHNuREUbO4M8xlwlQ8BgRE6_r0ti3pTJOusXiU309sFNdoQIKC1HFT86-4rWyW2qkrn1xt_l3BCCWF8GKMMfgAku1TJ</recordid><startdate>19890825</startdate><enddate>19890825</enddate><creator>서정진(Jung Jin Suh)</creator><creator>홍유화(You Hwa Hong)</creator><general>The Pharmaceutical Society Of Korea</general><general>대한약학회</general><scope>P5Y</scope><scope>SSSTE</scope><scope>JDI</scope></search><sort><creationdate>19890825</creationdate><title>1,4-디하드로피리딘 산류의 합성(II)</title><author>서정진(Jung Jin Suh) ; 홍유화(You Hwa Hong)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k602-365067a595c2d8aedec3b817742eb0158d54a3ccc28449513bfc92ed347feb003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1989</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>서정진(Jung Jin Suh)</creatorcontrib><creatorcontrib>홍유화(You Hwa Hong)</creatorcontrib><collection>Kyobo Scholar (교보스콜라)</collection><collection>Scholar(스콜라)</collection><collection>KoreaScience</collection><jtitle>Yaghag-hoi-ji</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>서정진(Jung Jin Suh)</au><au>홍유화(You Hwa Hong)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1,4-디하드로피리딘 산류의 합성(II)</atitle><jtitle>Yaghag-hoi-ji</jtitle><addtitle>Yakhak hoeji</addtitle><date>1989-08-25</date><risdate>1989</risdate><volume>33</volume><issue>4</issue><spage>219</spage><epage>225</epage><pages>219-225</pages><issn>0377-9556</issn><eissn>2383-9457</eissn><abstract>2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(2'-methylthio)ethyl ester methyl iodide salt (7a) was hydrolyzed by treatment with NaOH in aquous EtOH solution to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid mono methyl ester (2b) in 88% yield. By the same procedure, 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridinine-3,5-dicarboxylic acid 3-mono isopropyl ester (2c), 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2d), 2,6-dimethyl-4-(2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2e) and 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylic acid (2f) were obtained from the methyl iodide salts in 91-98% yield.</abstract><pub>The Pharmaceutical Society Of Korea</pub><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0377-9556 |
| ispartof | Yaghag-hoi-ji, 1989-08, Vol.33 (4), p.219-225 |
| issn | 0377-9556 2383-9457 |
| language | kor |
| recordid | cdi_kisti_ndsl_JAKO198903038861985 |
| source | Alma/SFX Local Collection |
| title | 1,4-디하드로피리딘 산류의 합성(II) |
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