아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가

아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가

Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were pre...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Yaghag-hoi-ji 1983-12, Vol.27 (4), p.309-314
Hauptverfasser: 김정균(Jack C. Kim), 윤이규(Li Kyu Yun), 고영심(Young Sim Koh), 윤웅찬(Ung Chan Yoon), 박무영(Moo Y. Pack), 문경호(Kyung Ho Moon)
Format: Artikel
Sprache:kor
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 314
container_issue 4
container_start_page 309
container_title Yaghag-hoi-ji
container_volume 27
creator 김정균(Jack C. Kim)
윤이규(Li Kyu Yun)
고영심(Young Sim Koh)
윤웅찬(Ung Chan Yoon)
박무영(Moo Y. Pack)
문경호(Kyung Ho Moon)
description Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were prepared by the treatment of the corresponding salt of amino acids with 2-chloroethyl isocyanate in cold water, followed by refluxing in concentrated HCl solution. Anticancer activity of the synthesized hydantoin derivatives were examined on murine leukemia L1210 cells growing in Fischer medium. Among them, 3-(2-chloroethy)-5-isobutyl-hydantoin (6c) showed substantially low $ED_{50}$ value of $9.6{\mu}g/ml$.
format Article
fullrecord <record><control><sourceid>kyobo_kisti</sourceid><recordid>TN_cdi_kisti_ndsl_JAKO198311919466543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4010023991887</sourcerecordid><originalsourceid>FETCH-LOGICAL-k607-f4e72379b923a63c2884d6e68087d52fa36f34afe88435c9a9e79a44f18d8e8d3</originalsourceid><addsrcrecordid>eNpNkD1Lw0Ach4MoWGq_QxZBh4O7-1_uZSzF90KX7uHSXGhoSKDJ0q1IHZxEtFCkCoJLB7EiaId-oub6HSwo4vTAw8Nv-G05FQoSkGKe2HYqGIRAyvP4rlPL8zjAwKmQAryKE9jxqHxblFcLezm302X5PC0_h-vR3AV0QFGjm2T9zBTdQXLodgehTossTsu7F_s4cdfjmR29rz6W7upr8ede7fjePt3ah5m7vrlezYd7zk6kk9zUfll12sdH7cYparZOzhr1JupxLFDEjKAgVKAoaA4dKiULueESSxF6NNLAI2A6MhsPXkdpZYTSjEVEhtLIEKrO_s9sL86L2E_DPPHP6xctoiQQoohinHsM_nWDLMj8IMt6HZMWpu8zTDCmoBSRm3O-AbP_cwQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가</title><source>Alma/SFX Local Collection</source><creator>김정균(Jack C. Kim) ; 윤이규(Li Kyu Yun) ; 고영심(Young Sim Koh) ; 윤웅찬(Ung Chan Yoon) ; 박무영(Moo Y. Pack) ; 문경호(Kyung Ho Moon)</creator><creatorcontrib>김정균(Jack C. Kim) ; 윤이규(Li Kyu Yun) ; 고영심(Young Sim Koh) ; 윤웅찬(Ung Chan Yoon) ; 박무영(Moo Y. Pack) ; 문경호(Kyung Ho Moon)</creatorcontrib><description>Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were prepared by the treatment of the corresponding salt of amino acids with 2-chloroethyl isocyanate in cold water, followed by refluxing in concentrated HCl solution. Anticancer activity of the synthesized hydantoin derivatives were examined on murine leukemia L1210 cells growing in Fischer medium. Among them, 3-(2-chloroethy)-5-isobutyl-hydantoin (6c) showed substantially low $ED_{50}$ value of $9.6{\mu}g/ml$.</description><identifier>ISSN: 0377-9556</identifier><identifier>EISSN: 2383-9457</identifier><language>kor</language><publisher>The Pharmaceutical Society Of Korea</publisher><ispartof>Yaghag-hoi-ji, 1983-12, Vol.27 (4), p.309-314</ispartof><rights>COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881</link.rule.ids></links><search><creatorcontrib>김정균(Jack C. Kim)</creatorcontrib><creatorcontrib>윤이규(Li Kyu Yun)</creatorcontrib><creatorcontrib>고영심(Young Sim Koh)</creatorcontrib><creatorcontrib>윤웅찬(Ung Chan Yoon)</creatorcontrib><creatorcontrib>박무영(Moo Y. Pack)</creatorcontrib><creatorcontrib>문경호(Kyung Ho Moon)</creatorcontrib><title>아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가</title><title>Yaghag-hoi-ji</title><addtitle>Yakhak hoeji</addtitle><description>Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were prepared by the treatment of the corresponding salt of amino acids with 2-chloroethyl isocyanate in cold water, followed by refluxing in concentrated HCl solution. Anticancer activity of the synthesized hydantoin derivatives were examined on murine leukemia L1210 cells growing in Fischer medium. Among them, 3-(2-chloroethy)-5-isobutyl-hydantoin (6c) showed substantially low $ED_{50}$ value of $9.6{\mu}g/ml$.</description><issn>0377-9556</issn><issn>2383-9457</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>JDI</sourceid><recordid>eNpNkD1Lw0Ach4MoWGq_QxZBh4O7-1_uZSzF90KX7uHSXGhoSKDJ0q1IHZxEtFCkCoJLB7EiaId-oub6HSwo4vTAw8Nv-G05FQoSkGKe2HYqGIRAyvP4rlPL8zjAwKmQAryKE9jxqHxblFcLezm302X5PC0_h-vR3AV0QFGjm2T9zBTdQXLodgehTossTsu7F_s4cdfjmR29rz6W7upr8ede7fjePt3ah5m7vrlezYd7zk6kk9zUfll12sdH7cYparZOzhr1JupxLFDEjKAgVKAoaA4dKiULueESSxF6NNLAI2A6MhsPXkdpZYTSjEVEhtLIEKrO_s9sL86L2E_DPPHP6xctoiQQoohinHsM_nWDLMj8IMt6HZMWpu8zTDCmoBSRm3O-AbP_cwQ</recordid><startdate>19831230</startdate><enddate>19831230</enddate><creator>김정균(Jack C. Kim)</creator><creator>윤이규(Li Kyu Yun)</creator><creator>고영심(Young Sim Koh)</creator><creator>윤웅찬(Ung Chan Yoon)</creator><creator>박무영(Moo Y. Pack)</creator><creator>문경호(Kyung Ho Moon)</creator><general>The Pharmaceutical Society Of Korea</general><general>대한약학회</general><scope>P5Y</scope><scope>SSSTE</scope><scope>JDI</scope></search><sort><creationdate>19831230</creationdate><title>아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가</title><author>김정균(Jack C. Kim) ; 윤이규(Li Kyu Yun) ; 고영심(Young Sim Koh) ; 윤웅찬(Ung Chan Yoon) ; 박무영(Moo Y. Pack) ; 문경호(Kyung Ho Moon)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k607-f4e72379b923a63c2884d6e68087d52fa36f34afe88435c9a9e79a44f18d8e8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1983</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>김정균(Jack C. Kim)</creatorcontrib><creatorcontrib>윤이규(Li Kyu Yun)</creatorcontrib><creatorcontrib>고영심(Young Sim Koh)</creatorcontrib><creatorcontrib>윤웅찬(Ung Chan Yoon)</creatorcontrib><creatorcontrib>박무영(Moo Y. Pack)</creatorcontrib><creatorcontrib>문경호(Kyung Ho Moon)</creatorcontrib><collection>Kyobo Scholar (교보스콜라)</collection><collection>Scholar(스콜라)</collection><collection>KoreaScience</collection><jtitle>Yaghag-hoi-ji</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>김정균(Jack C. Kim)</au><au>윤이규(Li Kyu Yun)</au><au>고영심(Young Sim Koh)</au><au>윤웅찬(Ung Chan Yoon)</au><au>박무영(Moo Y. Pack)</au><au>문경호(Kyung Ho Moon)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가</atitle><jtitle>Yaghag-hoi-ji</jtitle><addtitle>Yakhak hoeji</addtitle><date>1983-12-30</date><risdate>1983</risdate><volume>27</volume><issue>4</issue><spage>309</spage><epage>314</epage><pages>309-314</pages><issn>0377-9556</issn><eissn>2383-9457</eissn><abstract>Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were prepared by the treatment of the corresponding salt of amino acids with 2-chloroethyl isocyanate in cold water, followed by refluxing in concentrated HCl solution. Anticancer activity of the synthesized hydantoin derivatives were examined on murine leukemia L1210 cells growing in Fischer medium. Among them, 3-(2-chloroethy)-5-isobutyl-hydantoin (6c) showed substantially low $ED_{50}$ value of $9.6{\mu}g/ml$.</abstract><pub>The Pharmaceutical Society Of Korea</pub><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0377-9556
ispartof Yaghag-hoi-ji, 1983-12, Vol.27 (4), p.309-314
issn 0377-9556
2383-9457
language kor
recordid cdi_kisti_ndsl_JAKO198311919466543
source Alma/SFX Local Collection
title 아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T11%3A45%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-kyobo_kisti&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%EC%95%84%EB%AF%B8%EB%85%B8%EC%82%B0%EC%9C%BC%EB%A1%9C%EB%B6%80%ED%84%B0%203-(2-Chloroethyl)%20hydantoin%EB%93%A4%EC%9D%98%20%ED%95%A9%EC%84%B1%EA%B3%BC%20%EA%B7%B8%EB%93%A4%EC%9D%98%20%ED%95%AD%EC%95%94%EC%9E%91%EC%9A%A9%20%ED%8F%89%EA%B0%80&rft.jtitle=Yaghag-hoi-ji&rft.au=%EA%B9%80%EC%A0%95%EA%B7%A0(Jack%20C.%20Kim)&rft.date=1983-12-30&rft.volume=27&rft.issue=4&rft.spage=309&rft.epage=314&rft.pages=309-314&rft.issn=0377-9556&rft.eissn=2383-9457&rft_id=info:doi/&rft_dat=%3Ckyobo_kisti%3E4010023991887%3C/kyobo_kisti%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true