Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer

Objective The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2 mutations and BRCA1 methylation in women with OC. Met...

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Veröffentlicht in:	Obstetrics & gynecology science 2020-09, Vol.63 (5), p.643
Hauptverfasser:	Roshni D Kalachand, Ciaran O’riain, Sinead Toomey, Aoife Carr¸ Bsc, Kirsten M Timms, Sharon O’toole, Stephen Madden, Mark Bates, John J O’leary, Noreen Gleeson, Dearbhaile O’donnell, Liam Grogan, Oscar Breathnach, Angela Farrelly, Britta Stordal, Bryan T Hennessy
Format:	Artikel
Sprache:	kor
Schlagworte:	BRCA1 methylation BRCA1 mutation BRCA2 mutation Ovarian cancer
Online-Zugang:	Volltext
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