Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging

Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging

Background/Aims: This study aimed to compare the diagnostic performances of Liver Imaging Reporting and Data System (LI-RADS) 2018 and Korean Liver Cancer Association-National Cancer Center (KLCA-NCC) 2018 criteria on magnetic resonance imaging (MRI) for the noninvasive diagnosis of hepatocellular c...

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Veröffentlicht in:Clinical and molecular hepatology 2020-07, Vol.26 (3), p.340
Hauptverfasser: Sunyoung Lee, Seung-seob Kim, Dong Ryul Chang, Hyerim Kim, Myeong-jin Kim
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Carcinoma
Diagnosis
Hepatocellular
Magnetic resonance imaging
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container_issue 3
container_start_page 340
container_title Clinical and molecular hepatology
container_volume 26
creator Sunyoung Lee
Seung-seob Kim
Dong Ryul Chang
Hyerim Kim
Myeong-jin Kim
description Background/Aims: This study aimed to compare the diagnostic performances of Liver Imaging Reporting and Data System (LI-RADS) 2018 and Korean Liver Cancer Association-National Cancer Center (KLCA-NCC) 2018 criteria on magnetic resonance imaging (MRI) for the noninvasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients. Methods: This retrospective study included 273 treatment-naive patients (71 patients with extracellular contrast agent [ECA]-MRI and 202 patients with hepatobiliary agent [HBA]-MRI; 352 lesions including 263 HCCs) with high risk of HCC who underwent contrast-enhanced MRI between 2016 and 2017. Two readers evaluated all lesions according to the criteria of LI-RADS 2018 and KLCA-NCC 2018. The per-lesion diagnostic performances were compared using the generalized estimating equation method. Results: On ECA-MRI, the sensitivity and specificity of LI-RADS 2018 and KLCA-NCC 2018 were not significantly different (LR-5 vs. definite HCC: 75.8% vs. 69.4%, P=0.095 and 95.8% vs. 95.8%, P>0.999; LR-5/4 vs. definite/probable HCC: 87.1% vs.83.9%, P =0.313 and 87.5% vs. 91.7%, P =0.307). On HBA-MRI, definite HCC of KLCA-NCC 2018 showed significantly higher sensitivity (79.1% vs. 68.2%, P
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Methods: This retrospective study included 273 treatment-naive patients (71 patients with extracellular contrast agent [ECA]-MRI and 202 patients with hepatobiliary agent [HBA]-MRI; 352 lesions including 263 HCCs) with high risk of HCC who underwent contrast-enhanced MRI between 2016 and 2017. Two readers evaluated all lesions according to the criteria of LI-RADS 2018 and KLCA-NCC 2018. The per-lesion diagnostic performances were compared using the generalized estimating equation method. Results: On ECA-MRI, the sensitivity and specificity of LI-RADS 2018 and KLCA-NCC 2018 were not significantly different (LR-5 vs. definite HCC: 75.8% vs. 69.4%, P=0.095 and 95.8% vs. 95.8%, P&gt;0.999; LR-5/4 vs. definite/probable HCC: 87.1% vs.83.9%, P =0.313 and 87.5% vs. 91.7%, P =0.307). On HBA-MRI, definite HCC of KLCA-NCC 2018 showed significantly higher sensitivity (79.1% vs. 68.2%, P&lt;0.001) than LR-5 of LI-RADS 2018 without a significant difference in specificity (93.9% vs. 95.4%, P=0.314). Definite/probable HCC of KLCA-NCC 2018 had higher specificity (92.3% vs. 80.0%, P=0.003) than LR- 5/4 of LI-RADS 2018. The sensitivity was lower for definite/probable HCC than for LR-5/4 without statistical significance (85.6% vs. 88.1%, P =0.057). Conclusions: On ECA-MRI, LI-RADS 2018 and KLCA-NCC 2018 showed comparable diagnostic performances. On HBA-MRI, definite HCC of KLCA-NCC 2018 provided better sensitivity than LR-5 category of LI-RADS 2018 without compromising the specificity, while definite/probable HCC of KLCA-NCC 2018 revealed higher specificity than LR-5/4 of LI-RADS 2018 for diagnosing HCC. (Clin Mol Hepatol 2020;26:340-351)</description><identifier>ISSN: 2287-2728</identifier><language>kor</language><publisher>대한간학회</publisher><subject>Carcinoma ; Diagnosis ; Hepatocellular ; Magnetic resonance imaging</subject><ispartof>Clinical and molecular hepatology, 2020-07, Vol.26 (3), p.340</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Sunyoung Lee</creatorcontrib><creatorcontrib>Seung-seob Kim</creatorcontrib><creatorcontrib>Dong Ryul Chang</creatorcontrib><creatorcontrib>Hyerim Kim</creatorcontrib><creatorcontrib>Myeong-jin Kim</creatorcontrib><title>Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging</title><title>Clinical and molecular hepatology</title><addtitle>Clinical and Molecular Hepatology(대한간학회지)</addtitle><description>Background/Aims: This study aimed to compare the diagnostic performances of Liver Imaging Reporting and Data System (LI-RADS) 2018 and Korean Liver Cancer Association-National Cancer Center (KLCA-NCC) 2018 criteria on magnetic resonance imaging (MRI) for the noninvasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients. Methods: This retrospective study included 273 treatment-naive patients (71 patients with extracellular contrast agent [ECA]-MRI and 202 patients with hepatobiliary agent [HBA]-MRI; 352 lesions including 263 HCCs) with high risk of HCC who underwent contrast-enhanced MRI between 2016 and 2017. Two readers evaluated all lesions according to the criteria of LI-RADS 2018 and KLCA-NCC 2018. The per-lesion diagnostic performances were compared using the generalized estimating equation method. Results: On ECA-MRI, the sensitivity and specificity of LI-RADS 2018 and KLCA-NCC 2018 were not significantly different (LR-5 vs. definite HCC: 75.8% vs. 69.4%, P=0.095 and 95.8% vs. 95.8%, P&gt;0.999; LR-5/4 vs. definite/probable HCC: 87.1% vs.83.9%, P =0.313 and 87.5% vs. 91.7%, P =0.307). On HBA-MRI, definite HCC of KLCA-NCC 2018 showed significantly higher sensitivity (79.1% vs. 68.2%, P&lt;0.001) than LR-5 of LI-RADS 2018 without a significant difference in specificity (93.9% vs. 95.4%, P=0.314). Definite/probable HCC of KLCA-NCC 2018 had higher specificity (92.3% vs. 80.0%, P=0.003) than LR- 5/4 of LI-RADS 2018. The sensitivity was lower for definite/probable HCC than for LR-5/4 without statistical significance (85.6% vs. 88.1%, P =0.057). Conclusions: On ECA-MRI, LI-RADS 2018 and KLCA-NCC 2018 showed comparable diagnostic performances. On HBA-MRI, definite HCC of KLCA-NCC 2018 provided better sensitivity than LR-5 category of LI-RADS 2018 without compromising the specificity, while definite/probable HCC of KLCA-NCC 2018 revealed higher specificity than LR-5/4 of LI-RADS 2018 for diagnosing HCC. (Clin Mol Hepatol 2020;26:340-351)</description><subject>Carcinoma</subject><subject>Diagnosis</subject><subject>Hepatocellular</subject><subject>Magnetic resonance imaging</subject><issn>2287-2728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9jcFuwjAQRH2gEqjlC7jsD0QiTiC-IgOiAvVQuEeLcWBFso68gNRzfxxX7bmnkd680QzUSGtTZbrSZqjGInSclmVVFHk5G6lvG7oeI0lgCA3s3rPPxXIPepobQD7BdmcX2Ye1v6QJETgw8QOFHh5OhGcOQvKzvfgeb8H5tr23GMFhdMShQ7gL8Rm6pPobOYg-nSE7D5RYqt7US4Ot-PFfvqrJenWwm-xKInUfkxa_6sLk-Xxuiv_bJy0nSc0</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Sunyoung Lee</creator><creator>Seung-seob Kim</creator><creator>Dong Ryul Chang</creator><creator>Hyerim Kim</creator><creator>Myeong-jin Kim</creator><general>대한간학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>20200701</creationdate><title>Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging</title><author>Sunyoung Lee ; Seung-seob Kim ; Dong Ryul Chang ; Hyerim Kim ; Myeong-jin Kim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_38116683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2020</creationdate><topic>Carcinoma</topic><topic>Diagnosis</topic><topic>Hepatocellular</topic><topic>Magnetic resonance imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sunyoung Lee</creatorcontrib><creatorcontrib>Seung-seob Kim</creatorcontrib><creatorcontrib>Dong Ryul Chang</creatorcontrib><creatorcontrib>Hyerim Kim</creatorcontrib><creatorcontrib>Myeong-jin Kim</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>Clinical and molecular hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sunyoung Lee</au><au>Seung-seob Kim</au><au>Dong Ryul Chang</au><au>Hyerim Kim</au><au>Myeong-jin Kim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging</atitle><jtitle>Clinical and molecular hepatology</jtitle><addtitle>Clinical and Molecular Hepatology(대한간학회지)</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>26</volume><issue>3</issue><spage>340</spage><pages>340-</pages><issn>2287-2728</issn><abstract>Background/Aims: This study aimed to compare the diagnostic performances of Liver Imaging Reporting and Data System (LI-RADS) 2018 and Korean Liver Cancer Association-National Cancer Center (KLCA-NCC) 2018 criteria on magnetic resonance imaging (MRI) for the noninvasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients. Methods: This retrospective study included 273 treatment-naive patients (71 patients with extracellular contrast agent [ECA]-MRI and 202 patients with hepatobiliary agent [HBA]-MRI; 352 lesions including 263 HCCs) with high risk of HCC who underwent contrast-enhanced MRI between 2016 and 2017. Two readers evaluated all lesions according to the criteria of LI-RADS 2018 and KLCA-NCC 2018. The per-lesion diagnostic performances were compared using the generalized estimating equation method. Results: On ECA-MRI, the sensitivity and specificity of LI-RADS 2018 and KLCA-NCC 2018 were not significantly different (LR-5 vs. definite HCC: 75.8% vs. 69.4%, P=0.095 and 95.8% vs. 95.8%, P&gt;0.999; LR-5/4 vs. definite/probable HCC: 87.1% vs.83.9%, P =0.313 and 87.5% vs. 91.7%, P =0.307). On HBA-MRI, definite HCC of KLCA-NCC 2018 showed significantly higher sensitivity (79.1% vs. 68.2%, P&lt;0.001) than LR-5 of LI-RADS 2018 without a significant difference in specificity (93.9% vs. 95.4%, P=0.314). Definite/probable HCC of KLCA-NCC 2018 had higher specificity (92.3% vs. 80.0%, P=0.003) than LR- 5/4 of LI-RADS 2018. The sensitivity was lower for definite/probable HCC than for LR-5/4 without statistical significance (85.6% vs. 88.1%, P =0.057). Conclusions: On ECA-MRI, LI-RADS 2018 and KLCA-NCC 2018 showed comparable diagnostic performances. On HBA-MRI, definite HCC of KLCA-NCC 2018 provided better sensitivity than LR-5 category of LI-RADS 2018 without compromising the specificity, while definite/probable HCC of KLCA-NCC 2018 revealed higher specificity than LR-5/4 of LI-RADS 2018 for diagnosing HCC. (Clin Mol Hepatol 2020;26:340-351)</abstract><pub>대한간학회</pub><tpages>12</tpages></addata></record>
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subjects Carcinoma
Diagnosis
Hepatocellular
Magnetic resonance imaging
title Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging
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