Risk assessment of hepatocellular carcinoma development for indeterminate hepatic nodules in patients with chronic hepatitis B

Background/Aims: A risk prediction model for the development of hepatocellular carcinoma (HCC) from indeterminate nodules detected on computed tomography (CT) (RadCT score) in patients with chronic hepatitis B (CHB)-related cirrhosis was proposed. We validated this model for indeterminate nodules on...

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Veröffentlicht in:Clinical and molecular hepatology 2019-12, Vol.25 (4), p.390
Hauptverfasser: Haneulsaem Shin, Yeon Woo Jung, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-hyub Han, Yeun-yoon Kim, Jin-young Choi, Seung Up Kim
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container_issue 4
container_start_page 390
container_title Clinical and molecular hepatology
container_volume 25
creator Haneulsaem Shin
Yeon Woo Jung
Beom Kyung Kim
Jun Yong Park
Do Young Kim
Sang Hoon Ahn
Kwang-hyub Han
Yeun-yoon Kim
Jin-young Choi
Seung Up Kim
description Background/Aims: A risk prediction model for the development of hepatocellular carcinoma (HCC) from indeterminate nodules detected on computed tomography (CT) (RadCT score) in patients with chronic hepatitis B (CHB)-related cirrhosis was proposed. We validated this model for indeterminate nodules on magnetic resonance imaging (MRI). Methods: Between 2013 and 2016, Liver Imaging Reporting and Data System (LI-RADS) 2/3 nodules on MRI were detected in 99 patients with CHB. The RadCT score was calculated. Results: The median age of the 72 male and 27 female subjects was 58 years. HCC history and liver cirrhosis were found in 47 (47.5%) and 44 (44.4%) patients, respectively. The median RadCT score was 112. The patients with HCC (n=41, 41.4%) showed significantly higher RadCT scores than those without (median, 119 vs. 107; P=0.013); the Chinese university-HCC and risk estimation for HCC in CHB (REACH-B) scores were similar (both P>0.05). Arterial enhancement, T2 hyperintensity, and diffusion restriction on MRI were not significantly different in the univariate analysis (all P>0.05); only the RadCT score significantly predicted HCC (hazard ratio [HR]=1.018; P=0.007). Multivariate analysis showed HCC history was the only independent HCC predictor (HR=2.374; P=0.012). When the subjects were stratified into three risk groups based on the RadCT score (< 60, 60-105, and >105), the cumulative HCC incidence was not significantly different among them (all P>0.05, log-rank test). Conclusions: HCC history, but not RadCT score, predicted CHB-related HCC development from LI-RADS 2/3 nodules. New risk models optimized for MRI-defined indeterminate nodules are required. (Clin Mol Hepatol 2019;25:390-399)
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fullrecord <record><control><sourceid>kiss</sourceid><recordid>TN_cdi_kiss_primary_3739301</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>3739301</kiss_id><sourcerecordid>3739301</sourcerecordid><originalsourceid>FETCH-kiss_primary_37393013</originalsourceid><addsrcrecordid>eNp9y8EKwjAQBNAcFBTtF3jZHyjYphK9Kopn8S4x3dLFNCnZVPHit1utZ08DM29GYprna5XmKl9PRMJM12VRKCmzYjUVrxPxDTQzMjfoIvgKamx19Aat7awOYHQw5HyjocQ7Wt9-XeUDkCsxYmjI6YjDjQw4X3YWuV_hU_SY4UGxBlMH73owwEgM27kYV9oyJr-cicVhf94d0xsxX9pAjQ7Pi1RyI5eZ_L--AZf5TBE</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Risk assessment of hepatocellular carcinoma development for indeterminate hepatic nodules in patients with chronic hepatitis B</title><source>ProQuest One Community College</source><source>KoreaMed Synapse</source><source>KoreaMed Open Access</source><source>ProQuest Central (Alumni Edition)</source><source>DOAJ Directory of Open Access Journals</source><source>ProQuest Central UK/Ireland</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><source>ProQuest Central</source><creator>Haneulsaem Shin ; Yeon Woo Jung ; Beom Kyung Kim ; Jun Yong Park ; Do Young Kim ; Sang Hoon Ahn ; Kwang-hyub Han ; Yeun-yoon Kim ; Jin-young Choi ; Seung Up Kim</creator><creatorcontrib>Haneulsaem Shin ; Yeon Woo Jung ; Beom Kyung Kim ; Jun Yong Park ; Do Young Kim ; Sang Hoon Ahn ; Kwang-hyub Han ; Yeun-yoon Kim ; Jin-young Choi ; Seung Up Kim</creatorcontrib><description>Background/Aims: A risk prediction model for the development of hepatocellular carcinoma (HCC) from indeterminate nodules detected on computed tomography (CT) (RadCT score) in patients with chronic hepatitis B (CHB)-related cirrhosis was proposed. We validated this model for indeterminate nodules on magnetic resonance imaging (MRI). Methods: Between 2013 and 2016, Liver Imaging Reporting and Data System (LI-RADS) 2/3 nodules on MRI were detected in 99 patients with CHB. The RadCT score was calculated. Results: The median age of the 72 male and 27 female subjects was 58 years. HCC history and liver cirrhosis were found in 47 (47.5%) and 44 (44.4%) patients, respectively. The median RadCT score was 112. The patients with HCC (n=41, 41.4%) showed significantly higher RadCT scores than those without (median, 119 vs. 107; P=0.013); the Chinese university-HCC and risk estimation for HCC in CHB (REACH-B) scores were similar (both P&gt;0.05). Arterial enhancement, T2 hyperintensity, and diffusion restriction on MRI were not significantly different in the univariate analysis (all P&gt;0.05); only the RadCT score significantly predicted HCC (hazard ratio [HR]=1.018; P=0.007). Multivariate analysis showed HCC history was the only independent HCC predictor (HR=2.374; P=0.012). When the subjects were stratified into three risk groups based on the RadCT score (&lt; 60, 60-105, and &gt;105), the cumulative HCC incidence was not significantly different among them (all P&gt;0.05, log-rank test). Conclusions: HCC history, but not RadCT score, predicted CHB-related HCC development from LI-RADS 2/3 nodules. New risk models optimized for MRI-defined indeterminate nodules are required. (Clin Mol Hepatol 2019;25:390-399)</description><identifier>ISSN: 2287-2728</identifier><language>kor</language><publisher>대한간학회</publisher><subject>Computer-assisted; Liver neoplasms; Hepatitis B; Risk assessment; Hepatocellular carcinoma ; Radiographic image interpretation</subject><ispartof>Clinical and molecular hepatology, 2019-12, Vol.25 (4), p.390</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Haneulsaem Shin</creatorcontrib><creatorcontrib>Yeon Woo Jung</creatorcontrib><creatorcontrib>Beom Kyung Kim</creatorcontrib><creatorcontrib>Jun Yong Park</creatorcontrib><creatorcontrib>Do Young Kim</creatorcontrib><creatorcontrib>Sang Hoon Ahn</creatorcontrib><creatorcontrib>Kwang-hyub Han</creatorcontrib><creatorcontrib>Yeun-yoon Kim</creatorcontrib><creatorcontrib>Jin-young Choi</creatorcontrib><creatorcontrib>Seung Up Kim</creatorcontrib><title>Risk assessment of hepatocellular carcinoma development for indeterminate hepatic nodules in patients with chronic hepatitis B</title><title>Clinical and molecular hepatology</title><addtitle>Clinical and Molecular Hepatology(대한간학회지)</addtitle><description>Background/Aims: A risk prediction model for the development of hepatocellular carcinoma (HCC) from indeterminate nodules detected on computed tomography (CT) (RadCT score) in patients with chronic hepatitis B (CHB)-related cirrhosis was proposed. We validated this model for indeterminate nodules on magnetic resonance imaging (MRI). Methods: Between 2013 and 2016, Liver Imaging Reporting and Data System (LI-RADS) 2/3 nodules on MRI were detected in 99 patients with CHB. The RadCT score was calculated. Results: The median age of the 72 male and 27 female subjects was 58 years. HCC history and liver cirrhosis were found in 47 (47.5%) and 44 (44.4%) patients, respectively. The median RadCT score was 112. The patients with HCC (n=41, 41.4%) showed significantly higher RadCT scores than those without (median, 119 vs. 107; P=0.013); the Chinese university-HCC and risk estimation for HCC in CHB (REACH-B) scores were similar (both P&gt;0.05). Arterial enhancement, T2 hyperintensity, and diffusion restriction on MRI were not significantly different in the univariate analysis (all P&gt;0.05); only the RadCT score significantly predicted HCC (hazard ratio [HR]=1.018; P=0.007). Multivariate analysis showed HCC history was the only independent HCC predictor (HR=2.374; P=0.012). When the subjects were stratified into three risk groups based on the RadCT score (&lt; 60, 60-105, and &gt;105), the cumulative HCC incidence was not significantly different among them (all P&gt;0.05, log-rank test). Conclusions: HCC history, but not RadCT score, predicted CHB-related HCC development from LI-RADS 2/3 nodules. New risk models optimized for MRI-defined indeterminate nodules are required. 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We validated this model for indeterminate nodules on magnetic resonance imaging (MRI). Methods: Between 2013 and 2016, Liver Imaging Reporting and Data System (LI-RADS) 2/3 nodules on MRI were detected in 99 patients with CHB. The RadCT score was calculated. Results: The median age of the 72 male and 27 female subjects was 58 years. HCC history and liver cirrhosis were found in 47 (47.5%) and 44 (44.4%) patients, respectively. The median RadCT score was 112. The patients with HCC (n=41, 41.4%) showed significantly higher RadCT scores than those without (median, 119 vs. 107; P=0.013); the Chinese university-HCC and risk estimation for HCC in CHB (REACH-B) scores were similar (both P&gt;0.05). Arterial enhancement, T2 hyperintensity, and diffusion restriction on MRI were not significantly different in the univariate analysis (all P&gt;0.05); only the RadCT score significantly predicted HCC (hazard ratio [HR]=1.018; P=0.007). Multivariate analysis showed HCC history was the only independent HCC predictor (HR=2.374; P=0.012). When the subjects were stratified into three risk groups based on the RadCT score (&lt; 60, 60-105, and &gt;105), the cumulative HCC incidence was not significantly different among them (all P&gt;0.05, log-rank test). Conclusions: HCC history, but not RadCT score, predicted CHB-related HCC development from LI-RADS 2/3 nodules. New risk models optimized for MRI-defined indeterminate nodules are required. (Clin Mol Hepatol 2019;25:390-399)</abstract><pub>대한간학회</pub><tpages>10</tpages></addata></record>
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subjects Computer-assisted
Liver neoplasms
Hepatitis B
Risk assessment
Hepatocellular carcinoma
Radiographic image interpretation
title Risk assessment of hepatocellular carcinoma development for indeterminate hepatic nodules in patients with chronic hepatitis B
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