간경변증 환자의 급성 신부전 발생에 대한 소변 내 호중구 젤라틴 분해효소 연관 리포칼린의 임상적 의의
Background/Aims: A diagnosis of hepatorenal syndrome (HRS) is based on a differential evaluation of acute kidney injury (AKI), which may aggravate the clinical course. This study assessed the clinical significance of the urinary neutrophil gelatinase- associated lipocalin (u-NGAL) levels in a differ...
Gespeichert in:
| Veröffentlicht in: | The Korean journal of gastroenterology 2019-10, Vol.74 (4), p.212 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | kor |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 4 |
| container_start_page | 212 |
| container_title | The Korean journal of gastroenterology |
| container_volume | 74 |
| creator | 이종호 Jong Ho Lee 윤아일린 Eileen L. Yoon 박성은 Seong Eun Park 박지영 Ji Young Park 최정민 Jeong Min Choi 전태주 Tae Joo Jeon 신원창 Won Chang Shin 최원충 Won-choong Choi |
| description | Background/Aims: A diagnosis of hepatorenal syndrome (HRS) is based on a differential evaluation of acute kidney injury (AKI), which may aggravate the clinical course. This study assessed the clinical significance of the urinary neutrophil gelatinase- associated lipocalin (u-NGAL) levels in a differential diagnosis of AKI in patients with liver cirrhosis (LC).
Methods: Patients with LC who developed AKI were enrolled prospectively. Clinically, patients with AKI were classified into prerenal azotemia (PRA), HRS, and acute tubular necrosis (ATN) groups.
Results: Fifty-five patients (male, 74.5%) with LC who exhibited AKI upon admission were enrolled; 28, 9, and 18 patients were included in the PRA, HRS, and ATN groups, respectively. The baseline model for end-stage liver disease (MELD) scores was similar in the subgroups. The median event creatinine level, measured at the time of the AKI diagnosis, was similar in the HRS and ATN subgroups. On the other hand, the median event u-NGAL level differed significantly between the three subgroups (PRA, HRS, and ATN: 37 vs. 134 vs. 2,625 ng/mL, p=0.003). In particular, the median u-NGAL level of the HRS group was clearly different from those of the PRA (p |
| format | Article |
| fullrecord | <record><control><sourceid>kiss</sourceid><recordid>TN_cdi_kiss_primary_3707447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>3707447</kiss_id><sourcerecordid>3707447</sourcerecordid><originalsourceid>FETCH-kiss_primary_37074473</originalsourceid><addsrcrecordid>eNpjYeA0NLW00LW0tDTiYOAtLs5MMjA1MDc2Mbew5GToebWh5dWmva83N7xZNlfh7cwZb-ZNeDN3hsKrHZ1vWjYqvOle8Hpbw5sFLQqvN8x50zz3zfQJCq97Gt5OnaPwpq0HqEvhddMWhbczdrxZMvHV1jUKbxYseT13z9vuLQqvt7W8nbrl7awVQHUKb6ZveLUFqHbZmrf9a97s3PN62QaQJW_mtbxpbnyzoFEByAMiHgbWtMSc4lReKM3NIO3mGuLsoZudWVwcX1CUmZtYVBlvbG5gbmJiboxfFgA42XfG</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>간경변증 환자의 급성 신부전 발생에 대한 소변 내 호중구 젤라틴 분해효소 연관 리포칼린의 임상적 의의</title><source>KoreaMed Synapse</source><source>DOAJ Directory of Open Access Journals</source><source>KoreaMed Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>이종호 ; Jong Ho Lee ; 윤아일린 ; Eileen L. Yoon ; 박성은 ; Seong Eun Park ; 박지영 ; Ji Young Park ; 최정민 ; Jeong Min Choi ; 전태주 ; Tae Joo Jeon ; 신원창 ; Won Chang Shin ; 최원충 ; Won-choong Choi</creator><creatorcontrib>이종호 ; Jong Ho Lee ; 윤아일린 ; Eileen L. Yoon ; 박성은 ; Seong Eun Park ; 박지영 ; Ji Young Park ; 최정민 ; Jeong Min Choi ; 전태주 ; Tae Joo Jeon ; 신원창 ; Won Chang Shin ; 최원충 ; Won-choong Choi</creatorcontrib><description>Background/Aims: A diagnosis of hepatorenal syndrome (HRS) is based on a differential evaluation of acute kidney injury (AKI), which may aggravate the clinical course. This study assessed the clinical significance of the urinary neutrophil gelatinase- associated lipocalin (u-NGAL) levels in a differential diagnosis of AKI in patients with liver cirrhosis (LC).
Methods: Patients with LC who developed AKI were enrolled prospectively. Clinically, patients with AKI were classified into prerenal azotemia (PRA), HRS, and acute tubular necrosis (ATN) groups.
Results: Fifty-five patients (male, 74.5%) with LC who exhibited AKI upon admission were enrolled; 28, 9, and 18 patients were included in the PRA, HRS, and ATN groups, respectively. The baseline model for end-stage liver disease (MELD) scores was similar in the subgroups. The median event creatinine level, measured at the time of the AKI diagnosis, was similar in the HRS and ATN subgroups. On the other hand, the median event u-NGAL level differed significantly between the three subgroups (PRA, HRS, and ATN: 37 vs. 134 vs. 2,625 ng/mL, p=0.003). In particular, the median u-NGAL level of the HRS group was clearly different from those of the PRA (p<0.001) and ATN (p<0.001) groups. Multivariable analysis revealed the natural logarithm of the u-NGAL level (hazard ratio [HR] 1.77, p=0.031) and the MELD score (HR 1.17, p=0.027) to be independent prognostic factors for in-hospital mortality in patients with LC and AKI.
Conclusions: The median u-NGAL level differentiated HRS from ATN and served as a clinical indicator of in-hospital mortality for patients with LC and AKI. (Korean J Gastroenterol 2019;74:212-218)</description><identifier>ISSN: 1598-9992</identifier><language>kor</language><publisher>대한소화기학회</publisher><subject>acute; Liver cirrhosis ; Lipocalins; Acute kidney injury; Hepatorenal syndrome; Kidney tubular necrosis</subject><ispartof>The Korean journal of gastroenterology, 2019-10, Vol.74 (4), p.212</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>이종호</creatorcontrib><creatorcontrib>Jong Ho Lee</creatorcontrib><creatorcontrib>윤아일린</creatorcontrib><creatorcontrib>Eileen L. Yoon</creatorcontrib><creatorcontrib>박성은</creatorcontrib><creatorcontrib>Seong Eun Park</creatorcontrib><creatorcontrib>박지영</creatorcontrib><creatorcontrib>Ji Young Park</creatorcontrib><creatorcontrib>최정민</creatorcontrib><creatorcontrib>Jeong Min Choi</creatorcontrib><creatorcontrib>전태주</creatorcontrib><creatorcontrib>Tae Joo Jeon</creatorcontrib><creatorcontrib>신원창</creatorcontrib><creatorcontrib>Won Chang Shin</creatorcontrib><creatorcontrib>최원충</creatorcontrib><creatorcontrib>Won-choong Choi</creatorcontrib><title>간경변증 환자의 급성 신부전 발생에 대한 소변 내 호중구 젤라틴 분해효소 연관 리포칼린의 임상적 의의</title><title>The Korean journal of gastroenterology</title><addtitle>대한소화기학회지</addtitle><description>Background/Aims: A diagnosis of hepatorenal syndrome (HRS) is based on a differential evaluation of acute kidney injury (AKI), which may aggravate the clinical course. This study assessed the clinical significance of the urinary neutrophil gelatinase- associated lipocalin (u-NGAL) levels in a differential diagnosis of AKI in patients with liver cirrhosis (LC).
Methods: Patients with LC who developed AKI were enrolled prospectively. Clinically, patients with AKI were classified into prerenal azotemia (PRA), HRS, and acute tubular necrosis (ATN) groups.
Results: Fifty-five patients (male, 74.5%) with LC who exhibited AKI upon admission were enrolled; 28, 9, and 18 patients were included in the PRA, HRS, and ATN groups, respectively. The baseline model for end-stage liver disease (MELD) scores was similar in the subgroups. The median event creatinine level, measured at the time of the AKI diagnosis, was similar in the HRS and ATN subgroups. On the other hand, the median event u-NGAL level differed significantly between the three subgroups (PRA, HRS, and ATN: 37 vs. 134 vs. 2,625 ng/mL, p=0.003). In particular, the median u-NGAL level of the HRS group was clearly different from those of the PRA (p<0.001) and ATN (p<0.001) groups. Multivariable analysis revealed the natural logarithm of the u-NGAL level (hazard ratio [HR] 1.77, p=0.031) and the MELD score (HR 1.17, p=0.027) to be independent prognostic factors for in-hospital mortality in patients with LC and AKI.
Conclusions: The median u-NGAL level differentiated HRS from ATN and served as a clinical indicator of in-hospital mortality for patients with LC and AKI. (Korean J Gastroenterol 2019;74:212-218)</description><subject>acute; Liver cirrhosis</subject><subject>Lipocalins; Acute kidney injury; Hepatorenal syndrome; Kidney tubular necrosis</subject><issn>1598-9992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpjYeA0NLW00LW0tDTiYOAtLs5MMjA1MDc2Mbew5GToebWh5dWmva83N7xZNlfh7cwZb-ZNeDN3hsKrHZ1vWjYqvOle8Hpbw5sFLQqvN8x50zz3zfQJCq97Gt5OnaPwpq0HqEvhddMWhbczdrxZMvHV1jUKbxYseT13z9vuLQqvt7W8nbrl7awVQHUKb6ZveLUFqHbZmrf9a97s3PN62QaQJW_mtbxpbnyzoFEByAMiHgbWtMSc4lReKM3NIO3mGuLsoZudWVwcX1CUmZtYVBlvbG5gbmJiboxfFgA42XfG</recordid><startdate>20191031</startdate><enddate>20191031</enddate><creator>이종호</creator><creator>Jong Ho Lee</creator><creator>윤아일린</creator><creator>Eileen L. Yoon</creator><creator>박성은</creator><creator>Seong Eun Park</creator><creator>박지영</creator><creator>Ji Young Park</creator><creator>최정민</creator><creator>Jeong Min Choi</creator><creator>전태주</creator><creator>Tae Joo Jeon</creator><creator>신원창</creator><creator>Won Chang Shin</creator><creator>최원충</creator><creator>Won-choong Choi</creator><general>대한소화기학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>20191031</creationdate><title>간경변증 환자의 급성 신부전 발생에 대한 소변 내 호중구 젤라틴 분해효소 연관 리포칼린의 임상적 의의</title><author>이종호 ; Jong Ho Lee ; 윤아일린 ; Eileen L. Yoon ; 박성은 ; Seong Eun Park ; 박지영 ; Ji Young Park ; 최정민 ; Jeong Min Choi ; 전태주 ; Tae Joo Jeon ; 신원창 ; Won Chang Shin ; 최원충 ; Won-choong Choi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_37074473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2019</creationdate><topic>acute; Liver cirrhosis</topic><topic>Lipocalins; Acute kidney injury; Hepatorenal syndrome; Kidney tubular necrosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>이종호</creatorcontrib><creatorcontrib>Jong Ho Lee</creatorcontrib><creatorcontrib>윤아일린</creatorcontrib><creatorcontrib>Eileen L. Yoon</creatorcontrib><creatorcontrib>박성은</creatorcontrib><creatorcontrib>Seong Eun Park</creatorcontrib><creatorcontrib>박지영</creatorcontrib><creatorcontrib>Ji Young Park</creatorcontrib><creatorcontrib>최정민</creatorcontrib><creatorcontrib>Jeong Min Choi</creatorcontrib><creatorcontrib>전태주</creatorcontrib><creatorcontrib>Tae Joo Jeon</creatorcontrib><creatorcontrib>신원창</creatorcontrib><creatorcontrib>Won Chang Shin</creatorcontrib><creatorcontrib>최원충</creatorcontrib><creatorcontrib>Won-choong Choi</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>The Korean journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>이종호</au><au>Jong Ho Lee</au><au>윤아일린</au><au>Eileen L. Yoon</au><au>박성은</au><au>Seong Eun Park</au><au>박지영</au><au>Ji Young Park</au><au>최정민</au><au>Jeong Min Choi</au><au>전태주</au><au>Tae Joo Jeon</au><au>신원창</au><au>Won Chang Shin</au><au>최원충</au><au>Won-choong Choi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>간경변증 환자의 급성 신부전 발생에 대한 소변 내 호중구 젤라틴 분해효소 연관 리포칼린의 임상적 의의</atitle><jtitle>The Korean journal of gastroenterology</jtitle><addtitle>대한소화기학회지</addtitle><date>2019-10-31</date><risdate>2019</risdate><volume>74</volume><issue>4</issue><spage>212</spage><pages>212-</pages><issn>1598-9992</issn><abstract>Background/Aims: A diagnosis of hepatorenal syndrome (HRS) is based on a differential evaluation of acute kidney injury (AKI), which may aggravate the clinical course. This study assessed the clinical significance of the urinary neutrophil gelatinase- associated lipocalin (u-NGAL) levels in a differential diagnosis of AKI in patients with liver cirrhosis (LC).
Methods: Patients with LC who developed AKI were enrolled prospectively. Clinically, patients with AKI were classified into prerenal azotemia (PRA), HRS, and acute tubular necrosis (ATN) groups.
Results: Fifty-five patients (male, 74.5%) with LC who exhibited AKI upon admission were enrolled; 28, 9, and 18 patients were included in the PRA, HRS, and ATN groups, respectively. The baseline model for end-stage liver disease (MELD) scores was similar in the subgroups. The median event creatinine level, measured at the time of the AKI diagnosis, was similar in the HRS and ATN subgroups. On the other hand, the median event u-NGAL level differed significantly between the three subgroups (PRA, HRS, and ATN: 37 vs. 134 vs. 2,625 ng/mL, p=0.003). In particular, the median u-NGAL level of the HRS group was clearly different from those of the PRA (p<0.001) and ATN (p<0.001) groups. Multivariable analysis revealed the natural logarithm of the u-NGAL level (hazard ratio [HR] 1.77, p=0.031) and the MELD score (HR 1.17, p=0.027) to be independent prognostic factors for in-hospital mortality in patients with LC and AKI.
Conclusions: The median u-NGAL level differentiated HRS from ATN and served as a clinical indicator of in-hospital mortality for patients with LC and AKI. (Korean J Gastroenterol 2019;74:212-218)</abstract><pub>대한소화기학회</pub><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1598-9992 |
| ispartof | The Korean journal of gastroenterology, 2019-10, Vol.74 (4), p.212 |
| issn | 1598-9992 |
| language | kor |
| recordid | cdi_kiss_primary_3707447 |
| source | KoreaMed Synapse; DOAJ Directory of Open Access Journals; KoreaMed Open Access; EZB-FREE-00999 freely available EZB journals |
| subjects | acute Liver cirrhosis Lipocalins Acute kidney injury Hepatorenal syndrome Kidney tubular necrosis |
| title | 간경변증 환자의 급성 신부전 발생에 대한 소변 내 호중구 젤라틴 분해효소 연관 리포칼린의 임상적 의의 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T17%3A18%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-kiss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%EA%B0%84%EA%B2%BD%EB%B3%80%EC%A6%9D%20%ED%99%98%EC%9E%90%EC%9D%98%20%EA%B8%89%EC%84%B1%20%EC%8B%A0%EB%B6%80%EC%A0%84%20%EB%B0%9C%EC%83%9D%EC%97%90%20%EB%8C%80%ED%95%9C%20%EC%86%8C%EB%B3%80%20%EB%82%B4%20%ED%98%B8%EC%A4%91%EA%B5%AC%20%EC%A0%A4%EB%9D%BC%ED%8B%B4%20%EB%B6%84%ED%95%B4%ED%9A%A8%EC%86%8C%20%EC%97%B0%EA%B4%80%20%EB%A6%AC%ED%8F%AC%EC%B9%BC%EB%A6%B0%EC%9D%98%20%EC%9E%84%EC%83%81%EC%A0%81%20%EC%9D%98%EC%9D%98&rft.jtitle=The%20Korean%20journal%20of%20gastroenterology&rft.au=%EC%9D%B4%EC%A2%85%ED%98%B8&rft.date=2019-10-31&rft.volume=74&rft.issue=4&rft.spage=212&rft.pages=212-&rft.issn=1598-9992&rft_id=info:doi/&rft_dat=%3Ckiss%3E3707447%3C/kiss%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_kiss_id=3707447&rfr_iscdi=true |