Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth
Background/Aims Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with I...
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Veröffentlicht in: | Journal of neurogastroenterology and motility 2018-04, Vol.24 (2), p.307 |
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container_title | Journal of neurogastroenterology and motility |
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creator | Kee Wook Jung Myeognsook Seo Young Hwan Cho Young-ok Park So-yoon Yoon Jungbok Lee Dong-hoon Yang In Ja Yoon So Young Seo Hyo Jeong Lee Sang Hyoung Park Kyung Jo Kim Byong Duk Ye |
description | Background/Aims
Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with IBS with asymptomatic control individuals after excluding SIBO using the glucose hydrogen breath test (HBT).
Methods
Patients diagnosed with IBS and asymptomatic control individuals were enrolled prospectively. Dietary habits were assessed with the Food Frequency Questionnaire. After excluding SIBO, participants underwent HBTs with both 15 g and 25 g of fructose.
Results
Thirty-five patients with IBS and 35 age- and sex-matched asymptomatic control individuals were enrolled. The 15-g fructose HBT yielded positive results in 7 of the 35 (20.0%) patients with IBS and in 2 of 35 (5.7%) controls (P = 0.070). The 25-g fructose HBT was positive in 16 of the 35 (45.7%) patients with IBS and in 8 of the 35 (22.9%) controls (P = 0.040). Analysis of the Food Frequency Questionnaire responses showed no significant differences between the 2 groups in dietary intake, although patients with IBS showed a significantly higher mean fiber intake than controls (21.24 ± 11.35 g vs 15.87 ± 7.07 g, respectively, P = 0.040).
Conclusions
The 25-g fructose HBT identified FM in a significantly higher percentage of SIBO-negative patients with IBS than in asymptomatic control individuals, suggesting that FM may correlate with IBS. Education regarding dietary control of foods containing fructose may be useful for the management of patients with IBS.
(J Neurogastroenterol Motil 2018;24:307-316) |
format | Article |
fullrecord | <record><control><sourceid>kiss</sourceid><recordid>TN_cdi_kiss_primary_3596826</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>3596826</kiss_id><sourcerecordid>3596826</sourcerecordid><originalsourceid>FETCH-kiss_primary_35968263</originalsourceid><addsrcrecordid>eNp9ikFqAkEQRZuQQCTxBG7qAkJjk3FmqUGJixBBIUspxxqtpKZbqkuN-xw8swhZ5m3-g_9uXG_kqzD0ZTm-_fNxde_6OX_4jhC8L3zPfS-VzigUa4LUwFxPtaVM8IqC25z0aJwicIQlGlO0DO9sB1iosuFWCKbpQgKra9xpagkmjZHC7KuW047jHlYtisAiGmXjiAJTrLuCO3s7k-41Xezw6O4alEz9331wg_ls_fwy_OScN0flFvW6CU9VUY6K8P_7A2qqTwU</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth</title><source>Open Access: PubMed Central</source><source>KoreaMed Open Access</source><source>Free E-Journal (出版社公開部分のみ)</source><source>PubMed Central Open Access</source><creator>Kee Wook Jung ; Myeognsook Seo ; Young Hwan Cho ; Young-ok Park ; So-yoon Yoon ; Jungbok Lee ; Dong-hoon Yang ; In Ja Yoon ; So Young Seo ; Hyo Jeong Lee ; Sang Hyoung Park ; Kyung Jo Kim ; Byong Duk Ye</creator><creatorcontrib>Kee Wook Jung ; Myeognsook Seo ; Young Hwan Cho ; Young-ok Park ; So-yoon Yoon ; Jungbok Lee ; Dong-hoon Yang ; In Ja Yoon ; So Young Seo ; Hyo Jeong Lee ; Sang Hyoung Park ; Kyung Jo Kim ; Byong Duk Ye</creatorcontrib><description>Background/Aims
Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with IBS with asymptomatic control individuals after excluding SIBO using the glucose hydrogen breath test (HBT).
Methods
Patients diagnosed with IBS and asymptomatic control individuals were enrolled prospectively. Dietary habits were assessed with the Food Frequency Questionnaire. After excluding SIBO, participants underwent HBTs with both 15 g and 25 g of fructose.
Results
Thirty-five patients with IBS and 35 age- and sex-matched asymptomatic control individuals were enrolled. The 15-g fructose HBT yielded positive results in 7 of the 35 (20.0%) patients with IBS and in 2 of 35 (5.7%) controls (P = 0.070). The 25-g fructose HBT was positive in 16 of the 35 (45.7%) patients with IBS and in 8 of the 35 (22.9%) controls (P = 0.040). Analysis of the Food Frequency Questionnaire responses showed no significant differences between the 2 groups in dietary intake, although patients with IBS showed a significantly higher mean fiber intake than controls (21.24 ± 11.35 g vs 15.87 ± 7.07 g, respectively, P = 0.040).
Conclusions
The 25-g fructose HBT identified FM in a significantly higher percentage of SIBO-negative patients with IBS than in asymptomatic control individuals, suggesting that FM may correlate with IBS. Education regarding dietary control of foods containing fructose may be useful for the management of patients with IBS.
(J Neurogastroenterol Motil 2018;24:307-316)</description><identifier>ISSN: 2093-0879</identifier><identifier>EISSN: 2093-0887</identifier><language>kor</language><publisher>대한소화기기능성질환·운동학회</publisher><subject>Breath tests ; Dietary therapy ; Fructose ; Irritable bowel syndrome</subject><ispartof>Journal of neurogastroenterology and motility, 2018-04, Vol.24 (2), p.307</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Kee Wook Jung</creatorcontrib><creatorcontrib>Myeognsook Seo</creatorcontrib><creatorcontrib>Young Hwan Cho</creatorcontrib><creatorcontrib>Young-ok Park</creatorcontrib><creatorcontrib>So-yoon Yoon</creatorcontrib><creatorcontrib>Jungbok Lee</creatorcontrib><creatorcontrib>Dong-hoon Yang</creatorcontrib><creatorcontrib>In Ja Yoon</creatorcontrib><creatorcontrib>So Young Seo</creatorcontrib><creatorcontrib>Hyo Jeong Lee</creatorcontrib><creatorcontrib>Sang Hyoung Park</creatorcontrib><creatorcontrib>Kyung Jo Kim</creatorcontrib><creatorcontrib>Byong Duk Ye</creatorcontrib><title>Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth</title><title>Journal of neurogastroenterology and motility</title><addtitle>Journal of Neurogastroenterology and Motility</addtitle><description>Background/Aims
Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with IBS with asymptomatic control individuals after excluding SIBO using the glucose hydrogen breath test (HBT).
Methods
Patients diagnosed with IBS and asymptomatic control individuals were enrolled prospectively. Dietary habits were assessed with the Food Frequency Questionnaire. After excluding SIBO, participants underwent HBTs with both 15 g and 25 g of fructose.
Results
Thirty-five patients with IBS and 35 age- and sex-matched asymptomatic control individuals were enrolled. The 15-g fructose HBT yielded positive results in 7 of the 35 (20.0%) patients with IBS and in 2 of 35 (5.7%) controls (P = 0.070). The 25-g fructose HBT was positive in 16 of the 35 (45.7%) patients with IBS and in 8 of the 35 (22.9%) controls (P = 0.040). Analysis of the Food Frequency Questionnaire responses showed no significant differences between the 2 groups in dietary intake, although patients with IBS showed a significantly higher mean fiber intake than controls (21.24 ± 11.35 g vs 15.87 ± 7.07 g, respectively, P = 0.040).
Conclusions
The 25-g fructose HBT identified FM in a significantly higher percentage of SIBO-negative patients with IBS than in asymptomatic control individuals, suggesting that FM may correlate with IBS. Education regarding dietary control of foods containing fructose may be useful for the management of patients with IBS.
(J Neurogastroenterol Motil 2018;24:307-316)</description><subject>Breath tests</subject><subject>Dietary therapy</subject><subject>Fructose</subject><subject>Irritable bowel syndrome</subject><issn>2093-0879</issn><issn>2093-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9ikFqAkEQRZuQQCTxBG7qAkJjk3FmqUGJixBBIUspxxqtpKZbqkuN-xw8swhZ5m3-g_9uXG_kqzD0ZTm-_fNxde_6OX_4jhC8L3zPfS-VzigUa4LUwFxPtaVM8IqC25z0aJwicIQlGlO0DO9sB1iosuFWCKbpQgKra9xpagkmjZHC7KuW047jHlYtisAiGmXjiAJTrLuCO3s7k-41Xezw6O4alEz9331wg_ls_fwy_OScN0flFvW6CU9VUY6K8P_7A2qqTwU</recordid><startdate>20180430</startdate><enddate>20180430</enddate><creator>Kee Wook Jung</creator><creator>Myeognsook Seo</creator><creator>Young Hwan Cho</creator><creator>Young-ok Park</creator><creator>So-yoon Yoon</creator><creator>Jungbok Lee</creator><creator>Dong-hoon Yang</creator><creator>In Ja Yoon</creator><creator>So Young Seo</creator><creator>Hyo Jeong Lee</creator><creator>Sang Hyoung Park</creator><creator>Kyung Jo Kim</creator><creator>Byong Duk Ye</creator><general>대한소화기기능성질환·운동학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>20180430</creationdate><title>Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth</title><author>Kee Wook Jung ; Myeognsook Seo ; Young Hwan Cho ; Young-ok Park ; So-yoon Yoon ; Jungbok Lee ; Dong-hoon Yang ; In Ja Yoon ; So Young Seo ; Hyo Jeong Lee ; Sang Hyoung Park ; Kyung Jo Kim ; Byong Duk Ye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_35968263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2018</creationdate><topic>Breath tests</topic><topic>Dietary therapy</topic><topic>Fructose</topic><topic>Irritable bowel syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kee Wook Jung</creatorcontrib><creatorcontrib>Myeognsook Seo</creatorcontrib><creatorcontrib>Young Hwan Cho</creatorcontrib><creatorcontrib>Young-ok Park</creatorcontrib><creatorcontrib>So-yoon Yoon</creatorcontrib><creatorcontrib>Jungbok Lee</creatorcontrib><creatorcontrib>Dong-hoon Yang</creatorcontrib><creatorcontrib>In Ja Yoon</creatorcontrib><creatorcontrib>So Young Seo</creatorcontrib><creatorcontrib>Hyo Jeong Lee</creatorcontrib><creatorcontrib>Sang Hyoung Park</creatorcontrib><creatorcontrib>Kyung Jo Kim</creatorcontrib><creatorcontrib>Byong Duk Ye</creatorcontrib><collection>KISS</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>Journal of neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kee Wook Jung</au><au>Myeognsook Seo</au><au>Young Hwan Cho</au><au>Young-ok Park</au><au>So-yoon Yoon</au><au>Jungbok Lee</au><au>Dong-hoon Yang</au><au>In Ja Yoon</au><au>So Young Seo</au><au>Hyo Jeong Lee</au><au>Sang Hyoung Park</au><au>Kyung Jo Kim</au><au>Byong Duk Ye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth</atitle><jtitle>Journal of neurogastroenterology and motility</jtitle><addtitle>Journal of Neurogastroenterology and Motility</addtitle><date>2018-04-30</date><risdate>2018</risdate><volume>24</volume><issue>2</issue><spage>307</spage><pages>307-</pages><issn>2093-0879</issn><eissn>2093-0887</eissn><abstract>Background/Aims
Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with IBS with asymptomatic control individuals after excluding SIBO using the glucose hydrogen breath test (HBT).
Methods
Patients diagnosed with IBS and asymptomatic control individuals were enrolled prospectively. Dietary habits were assessed with the Food Frequency Questionnaire. After excluding SIBO, participants underwent HBTs with both 15 g and 25 g of fructose.
Results
Thirty-five patients with IBS and 35 age- and sex-matched asymptomatic control individuals were enrolled. The 15-g fructose HBT yielded positive results in 7 of the 35 (20.0%) patients with IBS and in 2 of 35 (5.7%) controls (P = 0.070). The 25-g fructose HBT was positive in 16 of the 35 (45.7%) patients with IBS and in 8 of the 35 (22.9%) controls (P = 0.040). Analysis of the Food Frequency Questionnaire responses showed no significant differences between the 2 groups in dietary intake, although patients with IBS showed a significantly higher mean fiber intake than controls (21.24 ± 11.35 g vs 15.87 ± 7.07 g, respectively, P = 0.040).
Conclusions
The 25-g fructose HBT identified FM in a significantly higher percentage of SIBO-negative patients with IBS than in asymptomatic control individuals, suggesting that FM may correlate with IBS. Education regarding dietary control of foods containing fructose may be useful for the management of patients with IBS.
(J Neurogastroenterol Motil 2018;24:307-316)</abstract><pub>대한소화기기능성질환·운동학회</pub><tpages>10</tpages></addata></record> |
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source | Open Access: PubMed Central; KoreaMed Open Access; Free E-Journal (出版社公開部分のみ); PubMed Central Open Access |
subjects | Breath tests Dietary therapy Fructose Irritable bowel syndrome |
title | Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth |
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