The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
Background: Slit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in...
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| Veröffentlicht in: | Endocrinology and metabolism (Seoul) 2017-09, Vol.32 (3), p.383 |
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| creator | Yea Eun Kang Sorim Choung Ju Hee Lee Hyun Jin Kim Bon Jeong Ku |
| description | Background: Slit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).
Methods: The participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was investigated in diabetic group compared with non-diabetic group. Additionally, the correlations between the se-rum level of Slit2 and diverse metabolic parameters were analyzed.
Results: Circulating Slit2 level was more decreased in diabetic group than in control group, but there was no significant difference statistically. Interestingly, serum levels of Slit2 were significantly negatively correlated to the serum concentrations of fasting glu-cose (coefficient r=-0.246, P=0.008), the serum concentrations of postprandial glucose (coefficient r=-0.233, P=0.017), and gly-cosylated hemoglobin (HbA1c; coefficient r=-0.357, P |
| format | Article |
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Methods: The participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was investigated in diabetic group compared with non-diabetic group. Additionally, the correlations between the se-rum level of Slit2 and diverse metabolic parameters were analyzed.
Results: Circulating Slit2 level was more decreased in diabetic group than in control group, but there was no significant difference statistically. Interestingly, serum levels of Slit2 were significantly negatively correlated to the serum concentrations of fasting glu-cose (coefficient r=-0.246, P=0.008), the serum concentrations of postprandial glucose (coefficient r=-0.233, P=0.017), and gly-cosylated hemoglobin (HbA1c; coefficient r=-0.357, P<0.001).
Conclusion: From our study, the first report of circulating Slit2 levels in human, circulating Slit2 level significantly negatively cor-related with serum glucose and HbA1c. Our results suggest that the circulating Slit2 may play a role in maintainence of glucose ho-meostasis in human, even though exact contribution and mechanism are not yet known.</description><identifier>ISSN: 2093-596X</identifier><language>kor</language><publisher>대한내분비학회</publisher><subject>Adipokines ; Adipose tissue ; Batokine ; brown ; Diabetes mellitus ; Slit2</subject><ispartof>Endocrinology and metabolism (Seoul), 2017-09, Vol.32 (3), p.383</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Yea Eun Kang</creatorcontrib><creatorcontrib>Sorim Choung</creatorcontrib><creatorcontrib>Ju Hee Lee</creatorcontrib><creatorcontrib>Hyun Jin Kim</creatorcontrib><creatorcontrib>Bon Jeong Ku</creatorcontrib><title>The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus</title><title>Endocrinology and metabolism (Seoul)</title><addtitle>Endocrinology and Metabolism</addtitle><description>Background: Slit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).
Methods: The participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was investigated in diabetic group compared with non-diabetic group. Additionally, the correlations between the se-rum level of Slit2 and diverse metabolic parameters were analyzed.
Results: Circulating Slit2 level was more decreased in diabetic group than in control group, but there was no significant difference statistically. Interestingly, serum levels of Slit2 were significantly negatively correlated to the serum concentrations of fasting glu-cose (coefficient r=-0.246, P=0.008), the serum concentrations of postprandial glucose (coefficient r=-0.233, P=0.017), and gly-cosylated hemoglobin (HbA1c; coefficient r=-0.357, P<0.001).
Conclusion: From our study, the first report of circulating Slit2 levels in human, circulating Slit2 level significantly negatively cor-related with serum glucose and HbA1c. Our results suggest that the circulating Slit2 may play a role in maintainence of glucose ho-meostasis in human, even though exact contribution and mechanism are not yet known.</description><subject>Adipokines</subject><subject>Adipose tissue</subject><subject>Batokine</subject><subject>brown</subject><subject>Diabetes mellitus</subject><subject>Slit2</subject><issn>2093-596X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpjYeA0MrA01jW1NIvgYOAtLs4yAAILCxNDI0NOhsiQjFSFoPycVIX8NAXnzKLk0pzEksy8dIXgnMwSIx2FEqC0fx5YFsT0Sy3PqVRwSizJz87MSy3WUcjMU_AozU3MU3DJTExKLUktVvBNzQFqLS3mYWBNS8wpTuWF0twM0m6uIc4eutmZxcXxBUWZuYlFlfHGpiaWRkYGxvhlAe6yOvI</recordid><startdate>20170930</startdate><enddate>20170930</enddate><creator>Yea Eun Kang</creator><creator>Sorim Choung</creator><creator>Ju Hee Lee</creator><creator>Hyun Jin Kim</creator><creator>Bon Jeong Ku</creator><general>대한내분비학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>20170930</creationdate><title>The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus</title><author>Yea Eun Kang ; Sorim Choung ; Ju Hee Lee ; Hyun Jin Kim ; Bon Jeong Ku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_35492203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2017</creationdate><topic>Adipokines</topic><topic>Adipose tissue</topic><topic>Batokine</topic><topic>brown</topic><topic>Diabetes mellitus</topic><topic>Slit2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yea Eun Kang</creatorcontrib><creatorcontrib>Sorim Choung</creatorcontrib><creatorcontrib>Ju Hee Lee</creatorcontrib><creatorcontrib>Hyun Jin Kim</creatorcontrib><creatorcontrib>Bon Jeong Ku</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>Endocrinology and metabolism (Seoul)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yea Eun Kang</au><au>Sorim Choung</au><au>Ju Hee Lee</au><au>Hyun Jin Kim</au><au>Bon Jeong Ku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus</atitle><jtitle>Endocrinology and metabolism (Seoul)</jtitle><addtitle>Endocrinology and Metabolism</addtitle><date>2017-09-30</date><risdate>2017</risdate><volume>32</volume><issue>3</issue><spage>383</spage><pages>383-</pages><issn>2093-596X</issn><abstract>Background: Slit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).
Methods: The participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was investigated in diabetic group compared with non-diabetic group. Additionally, the correlations between the se-rum level of Slit2 and diverse metabolic parameters were analyzed.
Results: Circulating Slit2 level was more decreased in diabetic group than in control group, but there was no significant difference statistically. Interestingly, serum levels of Slit2 were significantly negatively correlated to the serum concentrations of fasting glu-cose (coefficient r=-0.246, P=0.008), the serum concentrations of postprandial glucose (coefficient r=-0.233, P=0.017), and gly-cosylated hemoglobin (HbA1c; coefficient r=-0.357, P<0.001).
Conclusion: From our study, the first report of circulating Slit2 levels in human, circulating Slit2 level significantly negatively cor-related with serum glucose and HbA1c. Our results suggest that the circulating Slit2 may play a role in maintainence of glucose ho-meostasis in human, even though exact contribution and mechanism are not yet known.</abstract><pub>대한내분비학회</pub><tpages>6</tpages></addata></record> |
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| ispartof | Endocrinology and metabolism (Seoul), 2017-09, Vol.32 (3), p.383 |
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| language | kor |
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| source | KoreaMed Synapse; DOAJ Directory of Open Access Journals; PubMed Central Open Access; KoreaMed Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adipokines Adipose tissue Batokine brown Diabetes mellitus Slit2 |
| title | The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus |
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