BMB Reports : Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses

A nucleosomal protein, high mobility group box 1 (HMGB1) is known to be a late mediator of sepsis. Dabrafenib is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. Inhibition of HMGB1 and renewal of vascular integrity is appearing as an engaging therapeutic strate...

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Veröffentlicht in:	BMB reports 2016-04, Vol.49 (4), p.214
Hauptverfasser:	Byeongjin Jung, Hyejin Kang, Wonhwa Lee, Hyun Jin Noh, You Sun Kim, Min Su Han, Moon Chang Baek, Jaehong Kim, Jong Sup Bae
Format:	Artikel
Sprache:	kor
Schlagworte:	Barrier integrity Dabrafenib HMGB1 Sepsis
Online-Zugang:	Volltext
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