Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model
Background/Aims: The major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated by suppressing proinflammatory cytokines and downregulating cytosolic phos...
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| Veröffentlicht in: | Gut and liver 2014-01, Vol.8 (1), p.49 |
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| creator | Ji Hwan Lim Joo Hyun Kim Na Young Kim Byoung Hwan Lee Pyoung Ju Seo Jung Mook Kang So Young Jo Ji Hyun Park Ryoung Hee Nam Hyun Chang Jin Won Kwon Dong Ho Lee |
| description | Background/Aims: The major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated by suppressing proinflammatory cytokines and downregulating cytosolic phospholipase A2 (cPLA2), 5-lipoxy-genase (5-LOX), and the activation of calcitonin gene-related peptide. In this study, we evaluated the gastroprotective effects of SK-MS10 in the nonsteroidal anti-inflammatory drug (NSAID)-induced gastric damage rat model. Methods: The pretreatment effect of SK-MS10 was evaluated in the NSAID-induced gastric damage rat model using aspirin, indo-methacin, and diclofenac in 7-week-old rats. Gastric damage was evaluated based on the gross ulcer index by gastroen-terologists, and the damage area (%) was measured using the MetaMorph 7.0 video image analysis system. Myeloper-oxidase (MPO) was measured by enzyme-linked immunosor-bent assay, and Western blotting was used to analyze the levels of cyclooxygenase (COX)-1, COX-2, cPLA2, and 5-LOX. Results: All NSAIDs induced gastric damage based on the gross ulcer index and damage area (p |
| format | Article |
| fullrecord | <record><control><sourceid>kiss</sourceid><recordid>TN_cdi_kiss_primary_3198754</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>3198754</kiss_id><sourcerecordid>3198754</sourcerecordid><originalsourceid>FETCH-kiss_primary_31987543</originalsourceid><addsrcrecordid>eNp9TctOAkEQnAMm4uMLvPQPbMLuCgtHAot60IN6J52ZHhzYmSY9vUb-wk92MZ49VKpS1V01MuNy0cyKqprXl-Yq5_1kMiurZjo23w-YVfgorGQ1fBK03g8K2MOK7UdIZyBEjiwuWIQ3IgftlwoOVyHBC6esJBwcdrBMGoqn5DuMEZXlBGvpd4Pjeju8LW2vBL-TwcIaI-7o3IHwigrP7Ki7MRceu0y3f3xt7jbt--qxOISct0cJEeW0rcvFvJne1_-nP9PBT98</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>KoreaMed Open Access</source><source>PubMed Central</source><creator>Ji Hwan Lim ; Joo Hyun Kim ; Na Young Kim ; Byoung Hwan Lee ; Pyoung Ju Seo ; Jung Mook Kang ; So Young Jo ; Ji Hyun Park ; Ryoung Hee Nam ; Hyun Chang ; Jin Won Kwon ; Dong Ho Lee</creator><creatorcontrib>Ji Hwan Lim ; Joo Hyun Kim ; Na Young Kim ; Byoung Hwan Lee ; Pyoung Ju Seo ; Jung Mook Kang ; So Young Jo ; Ji Hyun Park ; Ryoung Hee Nam ; Hyun Chang ; Jin Won Kwon ; Dong Ho Lee</creatorcontrib><description>Background/Aims: The major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated by suppressing proinflammatory cytokines and downregulating cytosolic phospholipase A2 (cPLA2), 5-lipoxy-genase (5-LOX), and the activation of calcitonin gene-related peptide. In this study, we evaluated the gastroprotective effects of SK-MS10 in the nonsteroidal anti-inflammatory drug (NSAID)-induced gastric damage rat model. Methods: The pretreatment effect of SK-MS10 was evaluated in the NSAID-induced gastric damage rat model using aspirin, indo-methacin, and diclofenac in 7-week-old rats. Gastric damage was evaluated based on the gross ulcer index by gastroen-terologists, and the damage area (%) was measured using the MetaMorph 7.0 video image analysis system. Myeloper-oxidase (MPO) was measured by enzyme-linked immunosor-bent assay, and Western blotting was used to analyze the levels of cyclooxygenase (COX)-1, COX-2, cPLA2, and 5-LOX. Results: All NSAIDs induced gastric damage based on the gross ulcer index and damage area (p<0.05). Gastric dam-age was significantly attenuated by SK-MS10 pretreatment compared with NSAID treatment alone (p<0.05). The SK-MS10 pretreatment group exhibited lower MPO levels than the diclofenac group. The expression of cPLA2 and 5-LOX was decreased by SK-MS10 pretreatment in each of the three NSAID treatment groups. Conclusions: SK-MS10 exhibited a gastroprotective effect against NSAID-induced acute gastric damage in rats. However, its protective mechanism may be different across the three types of NSAID-induced gastric damage models in rats. (Gut Liver 2014;8:49-57)</description><identifier>ISSN: 1976-2283</identifier><language>kor</language><publisher>대한소화기학회</publisher><subject>Anti-inflammatory agents ; Arachidonate 5-lipoxygenase ; Cochinchina momordica ; cytosolic ; Gastroprotection ; non-steroidal ; Phospholipases A2</subject><ispartof>Gut and liver, 2014-01, Vol.8 (1), p.49</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Ji Hwan Lim</creatorcontrib><creatorcontrib>Joo Hyun Kim</creatorcontrib><creatorcontrib>Na Young Kim</creatorcontrib><creatorcontrib>Byoung Hwan Lee</creatorcontrib><creatorcontrib>Pyoung Ju Seo</creatorcontrib><creatorcontrib>Jung Mook Kang</creatorcontrib><creatorcontrib>So Young Jo</creatorcontrib><creatorcontrib>Ji Hyun Park</creatorcontrib><creatorcontrib>Ryoung Hee Nam</creatorcontrib><creatorcontrib>Hyun Chang</creatorcontrib><creatorcontrib>Jin Won Kwon</creatorcontrib><creatorcontrib>Dong Ho Lee</creatorcontrib><title>Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model</title><title>Gut and liver</title><addtitle>Gut and Liver</addtitle><description>Background/Aims: The major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated by suppressing proinflammatory cytokines and downregulating cytosolic phospholipase A2 (cPLA2), 5-lipoxy-genase (5-LOX), and the activation of calcitonin gene-related peptide. In this study, we evaluated the gastroprotective effects of SK-MS10 in the nonsteroidal anti-inflammatory drug (NSAID)-induced gastric damage rat model. Methods: The pretreatment effect of SK-MS10 was evaluated in the NSAID-induced gastric damage rat model using aspirin, indo-methacin, and diclofenac in 7-week-old rats. Gastric damage was evaluated based on the gross ulcer index by gastroen-terologists, and the damage area (%) was measured using the MetaMorph 7.0 video image analysis system. Myeloper-oxidase (MPO) was measured by enzyme-linked immunosor-bent assay, and Western blotting was used to analyze the levels of cyclooxygenase (COX)-1, COX-2, cPLA2, and 5-LOX. Results: All NSAIDs induced gastric damage based on the gross ulcer index and damage area (p<0.05). Gastric dam-age was significantly attenuated by SK-MS10 pretreatment compared with NSAID treatment alone (p<0.05). The SK-MS10 pretreatment group exhibited lower MPO levels than the diclofenac group. The expression of cPLA2 and 5-LOX was decreased by SK-MS10 pretreatment in each of the three NSAID treatment groups. Conclusions: SK-MS10 exhibited a gastroprotective effect against NSAID-induced acute gastric damage in rats. However, its protective mechanism may be different across the three types of NSAID-induced gastric damage models in rats. (Gut Liver 2014;8:49-57)</description><subject>Anti-inflammatory agents</subject><subject>Arachidonate 5-lipoxygenase</subject><subject>Cochinchina momordica</subject><subject>cytosolic</subject><subject>Gastroprotection</subject><subject>non-steroidal</subject><subject>Phospholipases A2</subject><issn>1976-2283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9TctOAkEQnAMm4uMLvPQPbMLuCgtHAot60IN6J52ZHhzYmSY9vUb-wk92MZ49VKpS1V01MuNy0cyKqprXl-Yq5_1kMiurZjo23w-YVfgorGQ1fBK03g8K2MOK7UdIZyBEjiwuWIQ3IgftlwoOVyHBC6esJBwcdrBMGoqn5DuMEZXlBGvpd4Pjeju8LW2vBL-TwcIaI-7o3IHwigrP7Ki7MRceu0y3f3xt7jbt--qxOISct0cJEeW0rcvFvJne1_-nP9PBT98</recordid><startdate>20140130</startdate><enddate>20140130</enddate><creator>Ji Hwan Lim</creator><creator>Joo Hyun Kim</creator><creator>Na Young Kim</creator><creator>Byoung Hwan Lee</creator><creator>Pyoung Ju Seo</creator><creator>Jung Mook Kang</creator><creator>So Young Jo</creator><creator>Ji Hyun Park</creator><creator>Ryoung Hee Nam</creator><creator>Hyun Chang</creator><creator>Jin Won Kwon</creator><creator>Dong Ho Lee</creator><general>대한소화기학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>20140130</creationdate><title>Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model</title><author>Ji Hwan Lim ; Joo Hyun Kim ; Na Young Kim ; Byoung Hwan Lee ; Pyoung Ju Seo ; Jung Mook Kang ; So Young Jo ; Ji Hyun Park ; Ryoung Hee Nam ; Hyun Chang ; Jin Won Kwon ; Dong Ho Lee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_31987543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2014</creationdate><topic>Anti-inflammatory agents</topic><topic>Arachidonate 5-lipoxygenase</topic><topic>Cochinchina momordica</topic><topic>cytosolic</topic><topic>Gastroprotection</topic><topic>non-steroidal</topic><topic>Phospholipases A2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji Hwan Lim</creatorcontrib><creatorcontrib>Joo Hyun Kim</creatorcontrib><creatorcontrib>Na Young Kim</creatorcontrib><creatorcontrib>Byoung Hwan Lee</creatorcontrib><creatorcontrib>Pyoung Ju Seo</creatorcontrib><creatorcontrib>Jung Mook Kang</creatorcontrib><creatorcontrib>So Young Jo</creatorcontrib><creatorcontrib>Ji Hyun Park</creatorcontrib><creatorcontrib>Ryoung Hee Nam</creatorcontrib><creatorcontrib>Hyun Chang</creatorcontrib><creatorcontrib>Jin Won Kwon</creatorcontrib><creatorcontrib>Dong Ho Lee</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>Gut and liver</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji Hwan Lim</au><au>Joo Hyun Kim</au><au>Na Young Kim</au><au>Byoung Hwan Lee</au><au>Pyoung Ju Seo</au><au>Jung Mook Kang</au><au>So Young Jo</au><au>Ji Hyun Park</au><au>Ryoung Hee Nam</au><au>Hyun Chang</au><au>Jin Won Kwon</au><au>Dong Ho Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model</atitle><jtitle>Gut and liver</jtitle><addtitle>Gut and Liver</addtitle><date>2014-01-30</date><risdate>2014</risdate><volume>8</volume><issue>1</issue><spage>49</spage><pages>49-</pages><issn>1976-2283</issn><abstract>Background/Aims: The major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated by suppressing proinflammatory cytokines and downregulating cytosolic phospholipase A2 (cPLA2), 5-lipoxy-genase (5-LOX), and the activation of calcitonin gene-related peptide. In this study, we evaluated the gastroprotective effects of SK-MS10 in the nonsteroidal anti-inflammatory drug (NSAID)-induced gastric damage rat model. Methods: The pretreatment effect of SK-MS10 was evaluated in the NSAID-induced gastric damage rat model using aspirin, indo-methacin, and diclofenac in 7-week-old rats. Gastric damage was evaluated based on the gross ulcer index by gastroen-terologists, and the damage area (%) was measured using the MetaMorph 7.0 video image analysis system. Myeloper-oxidase (MPO) was measured by enzyme-linked immunosor-bent assay, and Western blotting was used to analyze the levels of cyclooxygenase (COX)-1, COX-2, cPLA2, and 5-LOX. Results: All NSAIDs induced gastric damage based on the gross ulcer index and damage area (p<0.05). Gastric dam-age was significantly attenuated by SK-MS10 pretreatment compared with NSAID treatment alone (p<0.05). The SK-MS10 pretreatment group exhibited lower MPO levels than the diclofenac group. The expression of cPLA2 and 5-LOX was decreased by SK-MS10 pretreatment in each of the three NSAID treatment groups. Conclusions: SK-MS10 exhibited a gastroprotective effect against NSAID-induced acute gastric damage in rats. However, its protective mechanism may be different across the three types of NSAID-induced gastric damage models in rats. (Gut Liver 2014;8:49-57)</abstract><pub>대한소화기학회</pub><tpages>9</tpages></addata></record> |
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| ispartof | Gut and liver, 2014-01, Vol.8 (1), p.49 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; KoreaMed Open Access; PubMed Central |
| subjects | Anti-inflammatory agents Arachidonate 5-lipoxygenase Cochinchina momordica cytosolic Gastroprotection non-steroidal Phospholipases A2 |
| title | Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model |
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