Role of 18F-FDG PET Scans in Patients with Helicobacter pylori-Infected Gastric Low-Grade MALT Lymphoma
Background/Aims: Endoscopic ultrasound (EUS) plays a crucial role in the assessment and treatment of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma; however, interobserver variation, inadequate accuracy in judging the depth of tumor invasion, and histological heterogeneity of th...
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| Veröffentlicht in: | Gut and liver 2011-09, Vol.5 (3), p.308 |
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| creator | Kyung Ho Song Mijin Yun Jie Hyun Kim Woo Ick Yang Dae Ryong Kang Jae Bock Chung Yong Chan Lee |
| description | Background/Aims: Endoscopic ultrasound (EUS) plays a crucial role in the assessment and treatment of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma; however, interobserver variation, inadequate accuracy in judging the depth of tumor invasion, and histological heterogeneity of the tumor can limit its role. Thus, we have assessed the role of 18F-FDG PET scans in the management of Helicobacter pylori-infected gastric MALT lymphoma. Methods: Eighteen patients with H. pylori-infected low-grade gastric MALT lymphoma underwent an 18F-FDG PET scan prior to receiving H. pylori eradication therapy. We analyzed these patients` clinicopathologic data and measured the baseline and change in the metabolic activity of the tumor using standardized uptake values (SUVs). Results: Two patients failed to achieve complete remission of the low-grade gastric MALT lymphoma after successful H. pylori eradication. The baseline SUVs were significantly higher in these patients compared to successfully treated patients, 13.35±0.07 vs 2.98±0.93, respectively (n=2 vs n=16, p |
| format | Article |
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Thus, we have assessed the role of 18F-FDG PET scans in the management of Helicobacter pylori-infected gastric MALT lymphoma. Methods: Eighteen patients with H. pylori-infected low-grade gastric MALT lymphoma underwent an 18F-FDG PET scan prior to receiving H. pylori eradication therapy. We analyzed these patients` clinicopathologic data and measured the baseline and change in the metabolic activity of the tumor using standardized uptake values (SUVs). Results: Two patients failed to achieve complete remission of the low-grade gastric MALT lymphoma after successful H. pylori eradication. The baseline SUVs were significantly higher in these patients compared to successfully treated patients, 13.35±0.07 vs 2.98±0.93, respectively (n=2 vs n=16, p<0.001). The reduction in the SUV was significantly greater in the complete remission patients compared to treatment failure patients (p=0.018). Conclusions: A high SUV at baseline 18F-FDG PET and a lower reduction in the SUV within 3 months after eradication therapy are associated with treatment failure in H. pylori-positive low-grade gastric MALT lymphoma patients undergoing eradication treatment. (Gut Liver 2011;5:308-314)</description><identifier>ISSN: 1976-2283</identifier><language>kor</language><publisher>대한소화기학회</publisher><subject>Helicobacter pylori ; MALT Lymphoma ; Positron emission tomography ; Treatment failure</subject><ispartof>Gut and liver, 2011-09, Vol.5 (3), p.308</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Kyung Ho Song</creatorcontrib><creatorcontrib>Mijin Yun</creatorcontrib><creatorcontrib>Jie Hyun Kim</creatorcontrib><creatorcontrib>Woo Ick Yang</creatorcontrib><creatorcontrib>Dae Ryong Kang</creatorcontrib><creatorcontrib>Jae Bock Chung</creatorcontrib><creatorcontrib>Yong Chan Lee</creatorcontrib><title>Role of 18F-FDG PET Scans in Patients with Helicobacter pylori-Infected Gastric Low-Grade MALT Lymphoma</title><title>Gut and liver</title><addtitle>Gut and Liver</addtitle><description>Background/Aims: Endoscopic ultrasound (EUS) plays a crucial role in the assessment and treatment of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma; however, interobserver variation, inadequate accuracy in judging the depth of tumor invasion, and histological heterogeneity of the tumor can limit its role. Thus, we have assessed the role of 18F-FDG PET scans in the management of Helicobacter pylori-infected gastric MALT lymphoma. Methods: Eighteen patients with H. pylori-infected low-grade gastric MALT lymphoma underwent an 18F-FDG PET scan prior to receiving H. pylori eradication therapy. We analyzed these patients` clinicopathologic data and measured the baseline and change in the metabolic activity of the tumor using standardized uptake values (SUVs). Results: Two patients failed to achieve complete remission of the low-grade gastric MALT lymphoma after successful H. pylori eradication. The baseline SUVs were significantly higher in these patients compared to successfully treated patients, 13.35±0.07 vs 2.98±0.93, respectively (n=2 vs n=16, p<0.001). The reduction in the SUV was significantly greater in the complete remission patients compared to treatment failure patients (p=0.018). Conclusions: A high SUV at baseline 18F-FDG PET and a lower reduction in the SUV within 3 months after eradication therapy are associated with treatment failure in H. pylori-positive low-grade gastric MALT lymphoma patients undergoing eradication treatment. (Gut Liver 2011;5:308-314)</description><subject>Helicobacter pylori</subject><subject>MALT Lymphoma</subject><subject>Positron emission tomography</subject><subject>Treatment failure</subject><issn>1976-2283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9yU0LgjAcgPEdCrKXT9Dl_wUGU0vtGOVLYCDlXdacudJNtoH47evQudPDj2eGHPcQBtjzIn-Blsa8CAlcL9w76HlTHQfVgBslODmnUMQl3BmVBoSEglrBpTUwCttCxjvB1IMyyzUMU6e0wBfZ8K9rSKmxWjDI1YhTTWsO12NeQj71Q6t6ukbzhnaGb35doW0Sl6cMv4Ux1aBFT_VU-WTnBYT4_-8HnMQ-jg</recordid><startdate>20110930</startdate><enddate>20110930</enddate><creator>Kyung Ho Song</creator><creator>Mijin Yun</creator><creator>Jie Hyun Kim</creator><creator>Woo Ick Yang</creator><creator>Dae Ryong Kang</creator><creator>Jae Bock Chung</creator><creator>Yong Chan Lee</creator><general>대한소화기학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>20110930</creationdate><title>Role of 18F-FDG PET Scans in Patients with Helicobacter pylori-Infected Gastric Low-Grade MALT Lymphoma</title><author>Kyung Ho Song ; Mijin Yun ; Jie Hyun Kim ; Woo Ick Yang ; Dae Ryong Kang ; Jae Bock Chung ; Yong Chan Lee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_30426003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2011</creationdate><topic>Helicobacter pylori</topic><topic>MALT Lymphoma</topic><topic>Positron emission tomography</topic><topic>Treatment failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kyung Ho Song</creatorcontrib><creatorcontrib>Mijin Yun</creatorcontrib><creatorcontrib>Jie Hyun Kim</creatorcontrib><creatorcontrib>Woo Ick Yang</creatorcontrib><creatorcontrib>Dae Ryong Kang</creatorcontrib><creatorcontrib>Jae Bock Chung</creatorcontrib><creatorcontrib>Yong Chan Lee</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>Gut and liver</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kyung Ho Song</au><au>Mijin Yun</au><au>Jie Hyun Kim</au><au>Woo Ick Yang</au><au>Dae Ryong Kang</au><au>Jae Bock Chung</au><au>Yong Chan Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of 18F-FDG PET Scans in Patients with Helicobacter pylori-Infected Gastric Low-Grade MALT Lymphoma</atitle><jtitle>Gut and liver</jtitle><addtitle>Gut and Liver</addtitle><date>2011-09-30</date><risdate>2011</risdate><volume>5</volume><issue>3</issue><spage>308</spage><pages>308-</pages><issn>1976-2283</issn><abstract>Background/Aims: Endoscopic ultrasound (EUS) plays a crucial role in the assessment and treatment of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma; however, interobserver variation, inadequate accuracy in judging the depth of tumor invasion, and histological heterogeneity of the tumor can limit its role. Thus, we have assessed the role of 18F-FDG PET scans in the management of Helicobacter pylori-infected gastric MALT lymphoma. Methods: Eighteen patients with H. pylori-infected low-grade gastric MALT lymphoma underwent an 18F-FDG PET scan prior to receiving H. pylori eradication therapy. We analyzed these patients` clinicopathologic data and measured the baseline and change in the metabolic activity of the tumor using standardized uptake values (SUVs). Results: Two patients failed to achieve complete remission of the low-grade gastric MALT lymphoma after successful H. pylori eradication. The baseline SUVs were significantly higher in these patients compared to successfully treated patients, 13.35±0.07 vs 2.98±0.93, respectively (n=2 vs n=16, p<0.001). The reduction in the SUV was significantly greater in the complete remission patients compared to treatment failure patients (p=0.018). Conclusions: A high SUV at baseline 18F-FDG PET and a lower reduction in the SUV within 3 months after eradication therapy are associated with treatment failure in H. pylori-positive low-grade gastric MALT lymphoma patients undergoing eradication treatment. (Gut Liver 2011;5:308-314)</abstract><pub>대한소화기학회</pub><tpages>7</tpages></addata></record> |
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| ispartof | Gut and liver, 2011-09, Vol.5 (3), p.308 |
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| language | kor |
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| source | KoreaMed Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Helicobacter pylori MALT Lymphoma Positron emission tomography Treatment failure |
| title | Role of 18F-FDG PET Scans in Patients with Helicobacter pylori-Infected Gastric Low-Grade MALT Lymphoma |
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