Case Reports : Coinfection of hepatitis A virus genotype IA and IIIA complicated with autoimmune hemolytic anemia, prolonged cholestasis, and false positive immunoglobulin M anti hepatitis E virus: a case report
A 37-year-old male presented with fever and jaundice was diagnosed as hepatitis A complicated with progressive cholestasis and severe autoimmune hemolytic anemia. He was treated with high-dose prednisolone (1.5 mg/kg), and eventually recovered. His initial serum contained genotype IA hepatitis A vir...
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| Veröffentlicht in: | Clinical and molecular hepatology 2011-12, Vol.17 (4), p.323 |
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| container_title | Clinical and molecular hepatology |
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| creator | Hee Sup Kim Sook Hyang Jeong Je Hyuck Jang Hyung Joon Myung Jin Wook Kim Soo Mee Bang Sang Hoon Song Haer Young Kim Hae Sun Yun |
| description | A 37-year-old male presented with fever and jaundice was diagnosed as hepatitis A complicated with progressive cholestasis and severe autoimmune hemolytic anemia. He was treated with high-dose prednisolone (1.5 mg/kg), and eventually recovered. His initial serum contained genotype IA hepatitis A virus (HAV), which was subsequently replaced by genotype IIIA HAV. Moreover, at the time of development of hemolytic anemia, he became positive for immunoglobulin M (IgM) anti-hepatitis E virus (HEV). We detected HAV antigens in the liver biopsy specimen, while we detected neither HEV antigen in the liver nor HEV RNA in his serum. This is the first report of hepatitis A coinfected with two different genotypes manifesting with autoimmune hemolytic anemia, prolonged cholestasis, and false-positive IgM anti-HEV. (Korean J Hepatol 2011;17:323-327) |
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He was treated with high-dose prednisolone (1.5 mg/kg), and eventually recovered. His initial serum contained genotype IA hepatitis A virus (HAV), which was subsequently replaced by genotype IIIA HAV. Moreover, at the time of development of hemolytic anemia, he became positive for immunoglobulin M (IgM) anti-hepatitis E virus (HEV). We detected HAV antigens in the liver biopsy specimen, while we detected neither HEV antigen in the liver nor HEV RNA in his serum. This is the first report of hepatitis A coinfected with two different genotypes manifesting with autoimmune hemolytic anemia, prolonged cholestasis, and false-positive IgM anti-HEV. 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| identifier | ISSN: 2287-2728 |
| ispartof | Clinical and molecular hepatology, 2011-12, Vol.17 (4), p.323 |
| issn | 2287-2728 |
| language | kor |
| recordid | cdi_kiss_primary_2957621 |
| source | ProQuest One Community College; ProQuest Central (Alumni Edition); DOAJ Directory of Open Access Journals; ProQuest Central UK/Ireland; ProQuest Central |
| subjects | Coinfection Genotype Hemolytic anemia Hepatitis A virus Korea |
| title | Case Reports : Coinfection of hepatitis A virus genotype IA and IIIA complicated with autoimmune hemolytic anemia, prolonged cholestasis, and false positive immunoglobulin M anti hepatitis E virus: a case report |
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